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ABSTRACT Introduction Upper gastrointestinal endoscopy (UGIE) is a commonly performed procedure for evaluating complaints related to the upper gastrointestinal tract. It serves both diagnostic and therapeutic purposes. O...

Abstract Background Ciprofol is increasingly used for endoscopic sedation due to its reduced injection pain, but evidence regarding its safety when combined with etomidate in elderly patients remains limited. This study ...

Abstract Diagnosis of upper gastrointestinal (UGI) mucosal lesions primarily uses endoscopy. Based on our preliminary work in Zambia which showed that free blood in the stomach was associated with gastric mucosal lesions...

Theeran Gill, Guo Hou Loo, Guhan Muthkumaran, Nik Ritza Kosai Upper GI & Metabolic Surgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Guo H...

The majority of patients with cholecystolithiasis are asymptomatic. Hemobilia is a rare complication of cholecystolithiasis. It is also an uncommon cause of upper gastrointestinal hemorrhage, where the source of bleeding...

Abstract Background Adequate bowel preparation is critical for the success of pediatric colonoscopy. International guidelines recommend standardized low-volume regimens, although several studies also support individualiz...

Abstract Background Neuronal intranuclear inclusion disease (NIID) is a rare and progressive neurodegenerative disorder, distinguished by extreme clinical heterogeneity that frequently results in diagnostic delays. Whil...

ABSTRACT The biportal endoscopic technique, known as unilateral biportal endoscopy (UBE), has emerged as an effective minimally invasive approach for managing various spinal disorders. This report presents the first docu...

Introduction and importanceBouveret syndrome is a rare form of gallstone ileus characterized by gastric outlet obstruction secondary to impaction of a gallstone that has migrated into the gastrointestinal tract through a...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

Gastric metastases are rare, accounting for only 0.2%–0.7% of gastric malignancies. Gastric metastasis from primary popliteal fossa leiomyosarcoma (LMS) has not been previously reported. We report a 60-year-old female ...

BackgroundAlthough drug rash with eosinophilia and systemic symptoms (DRESS) and anticonvulsant hypersensitivity syndrome are well-known complications of anti-seizure medications (ASMs), lesser-known immunologic complica...

Abstract Background Patients with hypermobile Ehlers-Danlos Syndrome (hEDS) are at risk of developing craniocervical instability (CCI). Iatrogenic causes of CCI in hEDS are underreported. We describe a case series of hED...

Abstract Artificial intelligence (AI) is increasingly used in gastrointestinal endoscopy for polyp detection and classification. However, most AI models are trained on images from multiple video processors, whereas clini...

Colorectal cancer (CRC) remains a leading cause of global cancer-related morbidity and mortality. The majority of CRC cases arise through two well-established pathways: the conventional adenoma–carcinoma sequence and t...

Abstract Patient navigation is a promising intervention that could improve follow-up of abnormal fecal immunochemical test (FIT) results in colorectal cancer (CRC) screening. We describe changes in navigation activities ...

Abstract Background and aims Pancreatic duct leaks and fistulas are challenging complications of pancreatitis and pancreatic surgery. Although endoscopic retrograde pancreatic duct drainage (ERPD) is widely used, optimal...

Heba Mohamed Abdallah,1 Iman Shaban Osheba,1 Ahmed Abdallah Salman,2 Nahla K Gaballa,3 Merhan Osama Helmi,1 Amr Ragab Ibrahim,4 Asmaa Said Shahat Atta,1 Mohammed Gaber Saad,5 Sara Mohammed Aboagiza,1 Hanaa Saied Abdel Ha...

Abstract Introduction Dyspepsia affects 6.9% of people globally and significantly impairs quality of life, yet it often remains undiagnosed. Undiagnosed dyspepsia (UD) affects up to one-third of patients and is prevalent...

CARMIL2 is a protein required for T cell activation, specifically for CD28 and CARMA-1/PKC coupling and NF-kB signaling. CARMIL2 deficiency has pleiotropic presentations, which can include recurrent viral and mucocutaneo...

Abstract Background The recurrence of small intestinal hemorrhage (SIH) poses a significant clinical challenge owing to the absence of reliable and accessible predictive biomarkers. This study aimed to identify a crucial...

X-linked inhibitor of apoptosis (XIAP) is essential for innate and adaptive immune responses, including programmed cell death inhibition, NFkB and MAPK activation, NLRP3 inflammasome activity regulation, and TNFR signali...