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Materias / palabras clave: clinical trials, medical evidence, biomedicine; Medicine: Medicine (General)

Abstract Background Children with Unilateral Cerebral Palsy (UCP) are characterized by significant upper limbs (ULs) impairment that hinders daily activities and participation, requiring accurate assessment. Although mot...

Abstract Background Gait impairments following chronic neurological conditions, such as spinal cord injury (SCI), represent a major challenge for rehabilitation, with limited options to sustain functional recovery and pa...

BackgroundInnovation in long-term care for older adults is essential to manage challenges such as a growing demand and workforce shortages. Organizations with higher innovation readiness are more likely to adopt and sust...

Abstract Background Videocapsule endoscopy (VCE) is a valuable tool for investigating gastrointestinal (GI) diseases in dogs. Its use is not recommended in dogs ≤4.3 kg, because of risks of GI endoscopic capsule (EC)...

IntroductionVirtual control groups (VCGs) are proposed as a means to reduce reliance on live animals in preclinical toxicology studies. Despite the potential benefits of VCGs, concerns remain regarding their comparabilit...

Background Clinical lactation studies are valuable to guide pharmacotherapy during breastfeeding, but are not easy to conduct. This paper reports on challenges and mitigation strategies while conducting the UmbrelLACT st...

Abstract The accelerating consumption of electrical and electronic equipment (EEE) has led to rapid growth in waste electrical and electronic equipment (WEEE), which is currently the fastest-growing waste stream worldwid...

Abstract A compound oscillatory roller reducer (CORR) with a first-stage gear transmission and a second-stage oscillatory roller transmission is presented. The transmission principle of oscillatory roller transmission is...

Abstract Risk of bias assessment is a crucial step in evidence synthesis. The traditionally adopted tool, however, is complex, resource-intensive, and unreliable. While prior investigations have focused on whether Large ...

Despite the success of HER2-targeted antibody-drug conjugates (ADCs) in common cancers, there is a lack of real-world evidence regarding their role in rare tumors where ERBB2 gene amplification by next-generation sequenc...

Introduction There are national calls for reducing physician administrative burden. While interest in digital scribes (DS) is growing, there is limited evidence evaluating their safety and effectiveness. In contrast, hum...

James S Cho,1,2 Julia Zhu,2 Pritesh Topiwala,1,2 David Hao1,2 1Department of Anesthesiology, Mass General Brigham, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USACorrespondence: David Hao, Department of Anesthe...

The primary goal of this study is to examine the association between entrepreneurship and digital entrepreneurship, while exploring the moderating roles of gain assessment, loss assessment, and perceived feasibility. Usi...

Abstract Background Prior studies show significant increases in cardiorespiratory fitness (V̇O2max) and other health-related outcomes in response to reduced exertion high-intensity interval training (REHIT), yet these s...

Abstract Introduction Evoked compound action potentials (ECAPs) are neurophysiological biomarkers of neural activation during spinal cord stimulation (SCS). Clear distinction between ECAPs and nonphysiological signals is...

IntroductionDevelopmental Language Disorder (DLD) is a common neurodevelopmental condition that affects both the structural and pragmatic aspects of language. Conversational abilities—including topic initiation, mainte...

Abstract Background The rising global aging population has increased the prevalence of Alzheimer’s disease (AD), a condition with limited treatment options, making non-pharmacological interventions essential. While mob...

Abstract The relationship between the built environment and human emotional experience has received increasing attention in architectural and urban research. This study aims to collect fundamental background data from a ...

ABSTRACT Background and Aims Cardiovascular disease (CVD) remains the leading global cause of death, with 80% of deaths occurring in low‐ and middle‐income countries (LMICs). Improving access to screening and early d...

Abstract Background In 2014, the Consortium of Universities for Global Health (CUGH) developed a global health competency framework and called for its validation. Given China's increasing engagement in global health over...

Abstract Non-invasive fecal sampling is essential for molecular wildlife studies such as gut microbiome (GMB) research, yet field conditions often limit preservation options. To test the effects of preservation methods o...

AimsUnderstanding atypical forms of diabetes (AD) may advance precision medicine, but methods to identify such patients are needed. We propose an electronic health record (EHR)-based algorithmic approach to identify pati...