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Abstract This study investigates the synthesis and evaluation of glycine-conjugated 5.0G polypropyleneimine dendrimers as an advanced nanocarrier system for the selective delivery of chloroquine. 5.0G PPI dendrimers were...

Abstract Background With the widespread adoption of percutaneous coronary intervention (PCI), patients experiencing acute myocardial infarction (AMI) complicated by ventricular arrhythmia (VA) continue to encounter a sig...

BackgroundObesity is a major risk factor for lipotoxic cardiomyopathy, a process involving lipid metabolism disorders, inflammatory responses, and mitochondrial dysfunction. Salvia miltiorrhiza (Danshen), a traditional C...

With the continuous expansion of cyberspace boundaries, trust-related security incidents are increasing annually, posing severe challenges to the cyberspace trust system. However, current research mostly focuses on macro...

Abstract The IL-6 signalling pathway plays a significant role in the progression and development of squamous cell carcinoma (SCC). Bazedoxifene is a potent inhibitor of IL-6R; however, its efficacy is limited by its low ...

Biologic therapeutics have transformed the treatment of chronic and life-threatening diseases, yet their clinical use depends almost entirely on parenteral administration. Oral delivery is the preferred route for patient...

ABSTRACT Background Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments—including surgery, ch...

As an important strategic resource for safeguarding national information security and the healthy development of digital economy, cryptography is the cornerstone of protecting the security of critical infrastructure, gov...

The article provides a brief overview of the state of international political relations, states the transformation of the subjectivity of global processes and draws a conclusion about the crisis phenomena of modern globa...

Urban analytics has emerged as a transformative tool for addressing the challenges of urbanization and fostering sustainable smart cities. Despite its growing significance, a gap remains in the literature on integrating ...

Trends over time in the protected area coverage of Key Biodiversity Areas is an indicator to track progress for global environmental targets, including Sustainable Development Goals 14 and 15, and Target 3 of the Kunming...

Abstract The Error Diffusion Learning Algorithm (EDLA) is a learning scheme that performs synaptically local weight updates driven by a single, globally defined error signal. Although originally proposed as an alternativ...

Secure attachment of repair constructs to native cartilage and underlying bone tissues remains a major unmet need in chondral and osteochondral surgery. Currently existing injectable or scaffold-based cell carriers, whil...

The emergence of the generative artificial intelligence (GAI) tool ChatGPT in 2022 marked a turning point in the context of AI developments, but also in the ethical consideration of its use in various contexts, including...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

The development of efficient nonstoichiometric redox materials for solar-driven H₂O/CO₂ splitting via two-step thermochemical cycles requires optimization of redox thermodynamics, kinetics, and material stability. Th...

The incidence and mortality rates of breast cancer are increasing, although improvements in traditional treatments, and it remains the most frequent cancer among women globally. The increasing demand for natural suppleme...

A rising human impact alters landscape patterns and determines the agriculture–ecology–economy nexus (AEEN), which further threatens the sustainability of social–ecological system (SES). However, the mechanisms thr...

Herbal medicines have been extensively used for centuries owing to their therapeutic benefits and comparatively low incidence of adverse effects. Despite their clinical potential, the effectiveness of many herbal formula...

Formulation of the problem. In scientific research in sociology, education, physics, chemistry and other sciences, methods of correlation analysis are used. Correlation coefficients are used to determine the existence of...

Abstract Background Skin disorders are widespread, and there is increasing demand for reliable, standardized herbal therapeutics. Kumkumadi Tailam, a classical Ayurvedic polyherbal oil formulation, incorporates several b...

Synthesis of new drugs, their rational design, or isolation from natural sources has decreased, and these facts lead to the use of currently marketed drugs. Some of them, extensively used, show unfavorable properties rel...