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Iman Owliaee,1 Ali Teimoori,1 Mohammad Shoushtari,2 Ali Shojaeian3 1Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Virology, Pasteur Institute o...

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by heterogeneity in its genetic, epigenetic, and environmental etiologies, posing significant challenges for therapeutic development...

Gene therapy holds a great potential for treating a variety of human disorders by introducing foreign therapeutic genetic material into target cells using gene carriers (vectors). Most particularly, viral vectors show a ...

CD40L-deficient X-linked hyper IgM (XHIGM) syndrome is characterized by defective B cell class switching, deficiency of immunoglobulins G, A, and E, plus other immune abnormalities due to disrupted CD40L–CD40 interacti...

Abstract Sickle Cell Disease (SCD) remains a significant global health burden, disproportionately affecting low- and middle-income countries (LMICs), particularly in sub-Saharan Africa. Recent advancements in gene-based ...

IntroductionIn adults, Metacognitive therapy (MCT) for Generalized anxiety disorder (GAD) has demonstrated to be an effective treatment, and even superior to comparisons in randomized controlled trials. One explanation f...

Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...

Myxomatous mitral valve degeneration (MMVD) is the most common acquired heart disease in small and medium-sized dogs, leading to the development of chronic heart failure. The article summarizes current data (2020–2025)...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

BackgroundThis study examined the association between vitreous cellular repressor of E1A-stimulated genes 1 (CREG1) levels and the therapeutic response to ranibizumab in patients with diabetic macular edema (DME).Methods...

IntroductionAxillary bromhidrosis is characterized by excessive sweat gland activity and foul body odor, significantly affecting patients’ psychological well-being and social interactions.MethodsThis study recruited 30...

Despite the success of HER2-targeted antibody-drug conjugates (ADCs) in common cancers, there is a lack of real-world evidence regarding their role in rare tumors where ERBB2 gene amplification by next-generation sequenc...

Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder characterized by deficient production, secretion, or action of gonadotropin-releasing hormone (GnRH), the central regulator of the reproductive axis. We r...

Chronic generalized periodontitis (CGP) is a widespread inflammatory and destructive disease of periodontal tissues that leads to progressive destruction of supporting structures of the teeth and tooth loss. One of the k...

Abstract Background Young and middle-aged patients who simultaneously present with depression and obesity and who have undergone laparoscopic sleeve gastrectomy still face significant difficulties accessing mental health...

Introduction and aims: Subtype-specific differences in patient-reported outcomes (PROs) following periodontal therapy for gingivitis remain poorly defined. This study compared changes over time in clinical parameters, or...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Background and purpose: Mediastinal lymphoma patients are typically young and are at risk of long-term radiation-induced adverse events, making organ of interest (OOI) sparing a key objective of radiotherapy. This study ...

Abstract Background Estrogen receptor alpha (ERα)-positive luminal breast cancer is commonly treated with aromatase inhibitors (AI) to block estrogen signaling; however, resistance frequently develops, limiting therapy ...

Background and purpose: Proton therapy is a promising modality for treating locally advanced non-small cell lung cancer (LA-NSCLC). However, respiratory-induced intra-fractional motion can compromise tumour coverage. Thi...

Background and purpose: Robust optimization mitigates the effects of range and setup uncertainties in intensity–modulated proton therapy (IMPT) through robustness settings. However, it increases the dose to organs-at-r...

Background Menopausal transition is a period of psychological vulnerability, yet suicidality remains underassessed. Hormone replacement therapy (HRT) may influence mood symptoms, but its mental health effects – particu...

Abstract Background Multi-Family Therapy for Anorexia Nervosa (MFT-AN) unites families navigating similar difficulties to promote more rapid recovery for adolescents with eating disorders. Designed as a collaborative, gr...

Periodontitis, a chronic inflammatory disease induced by pathogenic microorganisms. Effective management requires the elimination of plaque biofilms, the suppression of oxidative stress, and the regeneration of periodont...