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Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts.

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Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts.

Jie Yuan et al · Public Library of Science (PLoS) · 2020 · ISSN 1553-7390

Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiologies and Polygenic R...

LCC LCC:GeneticsIdioma eng

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Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles.

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Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles.

Alejandro Martin-Trujillo et al · Public Library of Science (PLoS) · 2020 · ISSN 1553-7390

Although DNA methylation is the best characterized epigenetic mark, the mechanism by which it is targeted to specific regions in the genome remains unclear. Recent studies have revealed that local DNA methylation profile...

LCC LCC:GeneticsIdioma eng

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