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Materias / palabras clave: CRISPR; Genome engineering; Cas9; Genome editing; Guide RNA; Biology; Computational biology; Nuclease; Genome; Homology directed repair; Synthetic biology; Non-homologous end joining

Advanced materials, serving as the core material foundation underpinning economic transformation, national defense security, and technological revolution, directly determine national competitiveness through their researc...

ABSTRACT Genome engineering plays a crucial role in the rapidly growing fields of metabolic engineering and synthetic biology. Chromosomal integration and stable expression of functional genes or large metabolic pathways...

Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign n...

Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune ...

Materias / palabras clave: high-throughput computation, high-throughput preparation and characterization, high-throughput experiments, materials database, materials big-data technologies, digitalized and intelligent materials r&d; Technology: Elec...

Abstract Psammochloa villosa is a perennial herbaceous plant belonging to tribe Stipeae (Poaceae). It is mainly distributed in the arid and sandy Inner Mongolia Plateau and adjacent areas, demonstrating remarkable resili...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

Food texture is increasingly recognized as a determinant of nutritional safety, metabolic regulation, and overall health. However, conventional approaches to texture modification rely primarily on hydrocolloids, mechanic...

Abstract Background Several cyanobacterial strains are known to contain a high number of genome copies and elevated cell cycle dynamics. We systematically investigated the ploidy of the model cyanobacterium Synechocystis...

Abstract The plastic pollution crisis urges innovative recycling solutions. Promising approaches especially for polyester-containing wastes include enzymatic hydrolysis and microbial upcycling. For efficient enzymatic hy...

Background: The bacterial chromosome may be used to stably maintain foreign DNA in the mega-base range. Integration into the chromosome circumvents issues such as plasmid replication, stability, incompatibility, and copy...

ABSTRACT Upstream open reading frames (uORFs) are regulatory elements present in the 5′ leaders of mRNA that can significantly impact downstream gene expression in eukaryotes. In crop engineering, editing of uORFs can ...

Accelerating the discovery of advanced materials is essential for human welfare and sustainable, clean energy. In this paper, we introduce the Materials Project (www.materialsproject.org), a core program of the Materials...

Materias / palabras clave: Redundancy (engineering); Gene; Set (abstract data type); Database; Computer science; Computational biology; Ensembl; Biology; Data mining; Genomics; Genetics; Genome

The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and wide...

Materias / palabras clave: animal biotechnology, microbiology, genome engineering, domesticated animals, synthetic biology, immunogenetics; Technology: Chemical technology: Biotechnology

Materias / palabras clave: applied biochemistry, computational chemistry and drug discovery, genome engineering, cell engineering, antibody engineering, enzyme engineering; Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (Gen...

Materias / palabras clave: sequencing technologies, genome editing and genome engineering, imaging technologies, single-molecule methods, computational methods, machine learning; Technology: Chemical technology: Biotechnology; Science: Chemistry: ...

Materias / palabras clave: biosystems design, genome editing, synthetic genomics, biodesign theory, biological engineering, biodesign applications; Technology: Chemical technology: Biotechnology; Science: Biology (General): Genetics

Materias / palabras clave: synthetic biology, metabolic engineering, natural products, enzyme engineering, biosystems engineering, genome editing; Technology: Chemical technology: Biotechnology; Science: Biology (General)