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This study aimed to isolate and characterize lactic acid bacteria (LAB) from traditional Lithuanian fermented foods and evaluate their probiotic potential, safety, and ability to produce tryptophan. Around 20 LAB isolate...

The root-lesion nematode Pratylenchus vulnus parasitizes a wide range of hosts, including woody perennials such as walnut (Juglans regia) and grapevine (Vitis vinifera), significantly damaging roots and reducing yields. ...

The World Health Organization has identified ST23 carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) as a critical public health threat. Through China’s national surveillance system (BRICS), we identifi...

Abstract Studying microbial biodiversity offers enormous potential for improving the valorisation of plant biomass, particularly in conversion processes. Microorganisms, such as bacteria, fungi, yeasts and algae, play an...

Abstract Background Tuberculosis (TB) remains a critical global public health issue, particularly in rapidly urbanizing regions where population density and migration facilitate transmission. While whole-genome sequencin...

The RAG1 and RAG2 genes encode proteins essential for initiating V(D)J recombination in T cell receptor and immunoglobulin gene loci. Biallelic pathogenic variants in these genes are implicated in a spectrum of immunodef...

Abstract Transcriptome sequencing data offer a valuable resource for inferring genetic variants, yet their application in forensic individual identification and kinship analysis remains insufficiently explored. This stud...

ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regula...

Abstract Background Burkholderia pseudomallei, the causative agent of melioidosis, infects both humans and a broad range of animal species. While human disease has been well characterized, animal data are dispersed acros...

Abstract Populations residing in high-level natural radiation areas (HLNRA) along the monazite-rich coastal belt of Kerala, India, are chronically exposed to low-dose ionizing radiation, with lifetime cumulative doses ex...

Abstract Background Venom cocktails of cone snails are characterized by their dynamic composition and the rapid evolution of toxin-encoding genes due to various selective pressures. The integration of comparative genomic...

Abstract Background Antenatal hydronephrosis (AHN) is a common urological abnormality identified during prenatal ultrasound examination, with heterogeneous underlying causes. This study aimed to investigate the genetic e...

Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options following the failure of standard adjuvant therapies. We present a 54-year-old female with stage IV cortisol-secreting ACC that progres...

Abstract Background Comprehensive genomic analysis and optimal treatment for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) G719X + S768I co-mutations remain limited. This st...

The accumulation of polyethylene (PE) mulch films in agricultural soils represents a persistent environmental challenge. This study aimed to construct and evaluate efficient microbial consortia for PE biodegradation and ...

Abstract The nematode Ditylenchus destructor comprises multiple haplotypes with distinct host preferences, while the genetic basis remains unclear. We generate three genomes (Haplotypes A, B, and C) using hybrid assembly...

Abstract Background Preeclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains poorly characterized at the post-transcriptional regulation level. While alternative splicing (AS) perturbations drive...

Abstract Background Understanding the genetic evolution of HIV-1 Transmitted/Founder (T/F) virus is crucial for developing effective treatment and prevention strategies due to its rapid mutation and recombination rates. ...

PurposePreimplantation genetic testing for aneuploidy (PGT-A) is essential for selecting embryos free from chromosomal abnormalities before transfer. However, challenges such as detection failures, mosaicism, and the lim...

Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency and remains underdiagnosed in Brazil due to limited knowledge of its genetic landscape. Since 2024, the Centro Nacional d...

Abstract Background Hepatocellular carcinoma (HCC) is a critical condition characterized by unchecked cellular growth in the liver, often leading to systemic inflammation and organ failure. Although its complex molecular...

Abstract JMJD6, a bifunctional epigenetic modulator within the Jumonji C family, has garnered increasing attention for its potential roles in tumorigenesis, yet its pan-cancer prognostic and mechanistic significance rema...

BackgroundMango (Mangifera indica L.) is an economically important tropical fruit crop, yet the genomic diversity of mango germplasm from the Jazan region of Saudi Arabia—the country's primary production hub—remains ...

Abstract Background Tenacious glume a key trait limiting threshing efficiency in synthetic hexaploid wheat (SHW), represents an ancestral defense mechanism inherited from wild progenitors. Despite its evolutionary import...