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The root-lesion nematode Pratylenchus vulnus parasitizes a wide range of hosts, including woody perennials such as walnut (Juglans regia) and grapevine (Vitis vinifera), significantly damaging roots and reducing yields. ...

Abstract Studying microbial biodiversity offers enormous potential for improving the valorisation of plant biomass, particularly in conversion processes. Microorganisms, such as bacteria, fungi, yeasts and algae, play an...

The RAG1 and RAG2 genes encode proteins essential for initiating V(D)J recombination in T cell receptor and immunoglobulin gene loci. Biallelic pathogenic variants in these genes are implicated in a spectrum of immunodef...

This study aimed to isolate and characterize lactic acid bacteria (LAB) from traditional Lithuanian fermented foods and evaluate their probiotic potential, safety, and ability to produce tryptophan. Around 20 LAB isolate...

Abstract The nematode Ditylenchus destructor comprises multiple haplotypes with distinct host preferences, while the genetic basis remains unclear. We generate three genomes (Haplotypes A, B, and C) using hybrid assembly...

Background: ERBB2 aberrations are established oncogenic drivers with validated therapeutic relevance in breast cancer and emerging indications across solid tumors. In gastrointestinal malignancies, the prevalence, molecu...

Artemis-deficient severe combined immunodeficiency (SCID) is a rare autosomal recessive disorder caused by pathogenic variants in DCLRE1C, which encodes ARTEMIS, a DNA repair endonuclease essential for V(D)J recombinatio...

Plants frequently encounter diverse abiotic stresses, which require precise transcriptional regulation to maintain basic survival plasticity. The BES1 transcription factor family, a key component of brassinosteroid (BR) ...

Fungi are ubiquitous across nearly all habitats and play pivotal roles in maintaining ecological sustainability. Understanding the composition and functional roles of active fungal communities is essential for elucidatin...

IntroductionToll-like receptor 8 gain-of-function (TLR8 GOF) is a recently described inborn error of immunity caused by activating mutations in Tlr8. Pathogenic variants lead to constitutive signaling in myeloid cells an...

Abstract Background Zanthoxylum armatum is a vital economic crop in China, but its cultivation is challenged by abiotic stresses like drought and cold. Mitogen-activated protein kinase kinases (MAPKKs) are central signal...

Abstract Objective Thyroid-stimulating hormone beta subunit (TSHB) gene, a member of the glycoprotein hormone beta subunit family, has been detected in ovarian tissues and granulosa cells (GCs) of several species, sugges...

Abstract Background Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified s...

Abstract Recent advances in protein structure prediction have opened new avenues for understanding the potential impact of genetic mutations and how they might affect protein structure. In this study, we analyzed the dis...

Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...

Abstract Dietary protein plays a crucial role in shaping the gut microbiome and modulating intestinal amino acid metabolism. Gut microbiome is recognized as a reservoir for carrying antimicrobial resistance genes. Howeve...

The accumulation of polyethylene (PE) mulch films in agricultural soils represents a persistent environmental challenge. This study aimed to construct and evaluate efficient microbial consortia for PE biodegradation and ...

Abstract Improving cacao yield, a key objective in post-domestication crop improvement, remains a primary goal for breeders, but progress is often hindered by the confounding effects of population structure. To overcome ...

Abstract Medicinal leeches are rich in various antithrombotic components, holding significant pharmaceutical value. To investigate the differences in potential antithrombotic capacity among species, this study utilized t...

BackgroundEuschistus heros and Piezodorus guildinii are major soybean pests across the Americas. Gut-associated bacteria influence insect nutrition, detoxification, and stress tolerance, potentially enhancing adaptation ...

Abstract The Leschenault’s rousette (Rousettus leschenaultii) represents a medium-sized bat of the genus Rousettus that feeds on fruits or flowers, mainly distributed in Southeast Asia. Here, we generated a chromosome-...

Abstract Background The prognosis and progression mechanisms of bladder cancer (BLCA) are highly heterogeneous, driven by complex genetic and epigenetic alterations. This study aimed to construct a robust prognostic sign...

Oral mucosal ageing represents a fundamental reprogramming of the tissue microenvironment, a dynamic process that underlies the functional decline and heightened disease susceptibility observed in the elderly. This revie...

ABSTRACT Cancer is driven by genomic lesions and malignancy‐promoting transcriptional programs. In blood cancers, both are often interconnected as lesions frequently affect transcription factor (TF)‐encoding genes. T...