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ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regula...

Abstract Background The global rise of multidrug-resistant Enterobacterales, particularly extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae, poses a critical ...

Abstract Hepatic Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+IFDCS) is an extremely rare low-grade malignant tumor. Due to its rarity and lack of specific symptoms, laboratory markers,...

Abstract Prostate cancer continues to impose a significant health burden worldwide and in the United States, with rising incidence, persistent mortality rates, and disparities in both incidence and patient outcomes. Adva...

Abstract Background  The genomic and epigenetic landscape of the gasdermin family across cancers, and its clinical relevance, remain incompletely defined.  Methods Multi-omics features of gasdermins across 33 cancer ty...

Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options following the failure of standard adjuvant therapies. We present a 54-year-old female with stage IV cortisol-secreting ACC that progres...

Abstract The nematode Ditylenchus destructor comprises multiple haplotypes with distinct host preferences, while the genetic basis remains unclear. We generate three genomes (Haplotypes A, B, and C) using hybrid assembly...

ObjectiveTo analyze the etiological characteristics and homology of Vibrio parahaemolyticus strains isolated from two foodborne outbreaks in July 2024 in a county of Ningbo City.MethodsWhole genome sequencing was perform...

Abstract Background Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified s...

Fungi are ubiquitous across nearly all habitats and play pivotal roles in maintaining ecological sustainability. Understanding the composition and functional roles of active fungal communities is essential for elucidatin...

Background/Aim: In the pathogenesis of odontogenic tumors which arise from the rests of the dental apparatus in the jaw, several molecular pathways have been shown to play critical roles such as genetic alterations in th...

Abstract Whole-genome sequencing (WGS) of morphology-selected sperm pools provides an exploratory approach for investigating genomic features associated with variable sperm quality. In this study, pooled DNA from 1500 in...

Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be a...

IntroductionIntestinal ischemia-reperfusion (I/R) injury, a common and severe clinical condition with high morbidity and mortality, burdens healthcare systems. Our previous investigations established that a nano-delivery...

This report describes a rare case of a vascular-origin malignant tumor (intimal sarcoma or carcinosarcoma) extending from the right pulmonary hilum along the pulmonary artery in a 44-year-old man. The patient underwent r...

Abstract Background Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. Methods This review synthesized evidence through a protocol-...

Abstract Transcriptome sequencing data offer a valuable resource for inferring genetic variants, yet their application in forensic individual identification and kinship analysis remains insufficiently explored. This stud...

Abstract Polyunsaturated fatty acids (PUFAs) are important nutrients that play critical roles in sea urchin reproduction and early development. Strongylocentrotus intermedius, the only commercially cultured sea urchin sp...

Abstract Background Inflammatory bowel disease (IBD) represents a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract, primarily encompassing Crohn’s disease (CD) and ulcerative colitis ...

Plants frequently encounter diverse abiotic stresses, which require precise transcriptional regulation to maintain basic survival plasticity. The BES1 transcription factor family, a key component of brassinosteroid (BR) ...

Abstract Small-cell lung cancer (SCLC) has long been characterized by its aggressive clinical course and a deceptive initial sensitivity to chemotherapy that almost invariably yields to recalcitrant disease. Recent genom...

Abstract Fetal mortality significantly impacts reproductive efficiency in sheep, with approximately 30% of fetuses failing to survive until lambing. In multifetal gestation, partial litter loss (PLL) occurs in 28% to 37%...

Abstract Populations residing in high-level natural radiation areas (HLNRA) along the monazite-rich coastal belt of Kerala, India, are chronically exposed to low-dose ionizing radiation, with lifetime cumulative doses ex...

BackgroundOn-demand gene editing of autologous cells offers a novel therapeutic option for inborn errors of immunity (IEIs) caused by dominant-negative variants, which are often poorly addressed by conventional viral gen...