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Wuhua yellow chicken (WHYC) is an important traditional yellow-feathered chicken from China, which is characterized by its white tail feathers, white flight feathers, and strong disease resistance. However, the genomic b...

Abstract Background Drought intensity and frequency are increasing under global warming in the boreal forests, and breeding for drought resistance will facilitate adaptation of new planting material to changing climate c...

Graph-based pangenome references often misrepresent Copy Number Variations (CNVs) and Variable Number Tandem Repeats (VNTRs) as alternative acyclic paths, which hinders downstream analyses, degrades alignment behavior, a...

Abstract HER2-positive breast cancer exhibits marked genomic instability and heterogeneity, yet the clonal architecture and copy number variation (CNV) dynamics between ductal carcinoma in situ (DCIS) and invasive ductal...

Abstract Background Klebsiella pneumoniae complex (Kp) is a relevant neonatal pathogen colonizing preterm infants. While outbreak investigations often focus on multidrug-resistant strains, the epidemiology and genomic dy...

Abstract Background Comparative studies of mitochondrial genomes can assist in determining evolutionary and phylogenetic relationships. In the Ceratocystidaceae fungal family, mitochondrial genomes from only two genera a...

Abstract The nematode Ditylenchus destructor comprises multiple haplotypes with distinct host preferences, while the genetic basis remains unclear. We generate three genomes (Haplotypes A, B, and C) using hybrid assembly...

BackgroundMango (Mangifera indica L.) is an economically important tropical fruit crop, yet the genomic diversity of mango germplasm from the Jazan region of Saudi Arabia—the country's primary production hub—remains ...

Abstract Digitalis purpurea (foxglove) is a widely distributed ornamental plant. Here, we present a long read sequencing-based genome sequence of a magenta flowering D. purpurea plant and a corresponding prediction of ge...

The excessive and indiscriminate use of synthetic insecticides has led to environmental pollution, wildlife destruction, and adverse effects on human health, while simultaneously giving rise to resistance in insect pest ...

PurposePreimplantation genetic testing for aneuploidy (PGT-A) is essential for selecting embryos free from chromosomal abnormalities before transfer. However, challenges such as detection failures, mosaicism, and the lim...

Growth traits represent a main goal in aquaculture breeding programs and may be related to adaptive variation in wild fisheries. Integrating quantitative trait loci (QTL) mapping and next generation sequencing can greatl...

ABSTRACT Most plant genomes and their (post‐)transcriptional regulation remain unknown. We used SPLASH—a new, reference genome‐free sequence variation detection algorithm—to analyze transcriptional and post‐tra...

Multiple myeloma (MM) is best understood as a dynamically evolving genomic ecosystem shaped by inherited susceptibility, early oncogenic events, and continuous selective pressures. We propose an evolutionary genomics fra...

Abstract Background Terpenes and phenolic compounds are multifunctional plant metabolites that contribute to defense, signaling, and ecological interactions, while supporting industrial applications. Here, we implemented...

Bovine herpesvirus type 4 (BoHV-4) is a gamma-herpesvirus that has been isolated from apparently asymptomatic animals and from cattle with a variety of clinical signs. The pathogenic role of BoHV-4 remains unclear and i...

Increasing leaf dry matter and phenolic content in tomato has the potential to enhance plant resilience, a key requirement for food security and sustainable agriculture in the context of climate change. However, phenolic...

Abstract Transcriptome sequencing data offer a valuable resource for inferring genetic variants, yet their application in forensic individual identification and kinship analysis remains insufficiently explored. This stud...

Background: The relationship between vitamin D receptor gene variations and other risk factors in pulmonary tuberculosis remains unclear, largely due to the complex interplay of genetic and environmental factors. The pur...

Abstract Actinidia rufa is a valuable species for hybridization and introgressive breeding of new kiwifruit cultivars due to its exceptional tolerance to waterlogging. In this study, a chromosome-level genome of A. rufa ...

The HMGA1 (High Mobility Group AT-hook 1) gene is considered a candidate locus for growth- and fatness-related traits in pigs due to its involvement in transcriptional regulation and energy metabolism and its localizatio...

Cytogenetics has long represented a critical component in the clinical evaluation of hematologic malignancies. Chromosome banding studies provide a simultaneous snapshot of genome-wide copy number and structural variatio...

Neltuma spp. (previously known as Prosopis spp.) are vital for ecological restoration and sustainable forestry in arid and semiarid environments. Although extensively studied, nursery techniques are still inconsistently ...

Abstract Background Comparative genomics and plastome phylogenomics have advanced significantly in recent years, highlighting the diversity, possible admixture, and non-neutral evolution of the predominantly considered n...