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La neurociencia es la disciplina que, apoyada en diversas áreas del conocimiento, estudia científica e integralmente el sistema nervioso, desde los aspectos moleculares y celulares, los estudios más avanzados sobre el...

Materias / palabras clave: pathology, neoplasms, non-neoplastic diseases, inflammatory diseases, immune mediated diseases, iatrogenic diseases; Medicine: Pathology

Materias / palabras clave: pathology, neoplasms, inflammatory diseases, immune mediated diseases, iatrogenic diseases; Medicine: Pathology

Materias / palabras clave: ecology and ecoepidemiology of tick-borne diseases, tick-borne pathogens, tick-borne diseases in domestic animals and wildlife, tick-borne human diseases; Medicine: Internal medicine: Infectious and parasitic diseases

Materias / palabras clave: infectious diseases, epidemiology, public health, humans, animals, birds; Medicine: Internal medicine: Infectious and parasitic diseases

Materias / palabras clave: zoonotic diseases, zoonoses and public health, veterinary medicine, infectious diseases, veterinary and human health, one health; Science: Physiology: Animal biochemistry | Agriculture: Animal culture: Veterinary medicin...

Materias / palabras clave: communicable human diseases, non-communicable human diseases; Medicine: Medicine (General)

Materias / palabras clave: human immunology, human diseases, immunotherapy, autoimmunity; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Forkhead box P3 (FOXP3) is the master transcription factor of regulatory T cells (Tregs) and is essential for maintaining immune tolerance. FOXP3 is stably expressed in Tregs, driving their suppressive function, and it i...

IntroductionOSMR encodes oncostatin M receptor beta (OSMRβ), a cell surface receptor of the gp130 family that binds OSM and IL-31, and is highly expressed on fibroblasts. The gp130 family comprises signaling proteins, m...

BackgroundCongenital athymia (CA) is a rare T cell immune deficiency, fatal without curative treatment with allogeneic processed thymus tissue–agdc (RETHYMIC) implantation (here termed CTTI). The rate and extent of T c...

We previously reported that inherited human retinoic acid-related orphan receptor gamma T (RORγT) deficiency underlies mycobacterial disease and chronic mucocutaneous candidiasis (CMC) in seven patients from three ances...

IntroductionNeutrophils, the most abundant leukocyte population, play a central role in host defense against group B Streptococcus (GBS), an encapsulated bacterium that frequently causes severe infections in humans, incl...

Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyo...

Noncommunicable diseases (NCDs) are the leading cause of morbidity, mortality, and disability in the Americas. NCDs are largely preventable because of the modifiable nature of their risk factors, including the elevated c...

BackgroundThe research on human microbiota-associated (HMA) animal models is an important tool for studying the human microbiome and holds great potential for elucidating disease mechanisms and microbe-based therapeutic ...

Informes de la OIT y la OMS, sobre enfermedades y accidentes de trabajo, aseguran que el uso de productos agroquímicos y plaguicidas provoca unas setenta mil muertes por envenenamiento cada año, a nivel mundial, y al m...

Microplastics (MPs), environmental pollutants resulting from the degradation of plastic products and industrial processes, have become ubiquitous in global ecosystems. MPs can enter the human body through ingestion, inha...

Abstract Background Developing regenerative therapies to restore kidney function in patients with progressive renal disease represents a major challenge for modern molecular nephrology. Kidney organoids, three-dimensiona...

Growing evidence has directly linked the gastrointestinal tract, gut microbiota, and central nervous system, forming the gut-brain axis, a process that has been described as a key mechanism in regulating neurological pro...

Background: Copper (Cu) is an essential trace metal used as a catalytic cofactor for many enzymes. However, it can have nocive effects when it participates in the Fenton reaction, producing reactive oxygen species (ROS)....

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

Reactive oxygen particles can increase tissue injury in the pathogenesis of human diseases. However, some antioxidants are used for therapeutic approach. In this review, the possible roles of reactive oxygen particles ...

Respiratory tract disease can be associated with primary or secondary bacterial infections in dogs and cats and is a common reason for use and potential misuse, improper use, and overuse of antimicrobials. There is a lac...