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ObjectivesImmunocompromised patients with B-cell depletion are at risk of ongoing SARS-CoV-2 replication that can lead to intra-host genomic divergence, immune escape during treatment and potentially emergence of novel v...

Abstract Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary malignant tumors with poor prognosis and limited therapeutic options. Recent studies have highlighted the role of the immune system in the deve...

Studies to prevent organ rejection in renal transplant patients are continuing. Improvement in HLA-matching and efficiency of immunosuppressive drugs are the most important factors. In this study, effects of single or th...

OBJECTIVE: The aim of our study was to determine the effect and safety of low dose tacrolimus instead of switching to cyclosporine in patients with new onset diabetes after renal transplantation (NODAT) associated with t...

ABSTRACT A 2‐year‐old female spayed British Shorthair cat was diagnosed with immune‐mediated thrombocytopenia (ITP) after presenting with a 3‐week history of gastrointestinal bleeding and anemia. Treatment with a...

Materias / palabras clave: Cytokine storm; Coronavirus disease 2019 (COVID-19); Immunosuppression; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Storm; Cytokine; Betacoronavirus; Virology; Co...

Abstract B and T lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) are emerging immune checkpoint molecules implicated in immune dysregulation during critical illness. We investigated the prognostic rel...

Abstract Haematological malignancies (HMs) are characterized by profound immune dysregulation, which increases susceptibility to sepsis. This dysregulation arises from the underlying disease and may be exacerbated by tre...

ABSTRACT Mutation‐intolerant genes (MIGs), which are constrained in tumors yet variable in normal tissues, are critical for cancer survival. Herein, we developed miDriver, a computational framework using pancancer‐no...

The targeted-modified low-molecular-weight pectin (LMP), a natural polysaccharide derived from citrus fruits, represents a promising food-derived immunomodulatory agent. This study assessed the efficacy of targeted-modif...

Opioids remain central to managing moderate to severe pain, yet they also produce significant and often under-recognized effects on the immune system. In this narrative review, we synthesize evidence from 1994 to 2025 ac...

OBJETIVO: avaliar a toxicidade do tacrolimus sobre o desenvolvimento embrionário em ratas tratadas durante o período de trânsito tubário. MÉTODOS: sessenta ratas Wistar foram distribuídas em quatro grupos (15 anima...

Lung transplantation (LTx) remains limited by high immunogenicity and chronic rejection, yet the application of donor-specific blood transfusion (DSBT) in LTx has not been fully investigated. We established a murine orth...

OBJECTIVE: Although BK virus nephropathy (BKVN) has mostly been reported to occur in transplanted kidneys, there has been a gradual increase in cases of BKVN in the native kidney. This study was directed towards investig...

OBJETIVO: avaliar as inter-relações recíprocas entre o transplante renal e a gravidez por meio da análise das intercorrências clínicas e obstétricas, bem como da investigação do desfecho perinatal. MÉTODOS: foi...

Abstract Background The tumor immune microenvironment (TIME) of canine and feline mammary carcinomas (CMC and FMC) comprises a complex collection of immune cells that remains underinvestigated. We performed extensive imm...

OBJECTIVE: The aim of our study was to compare the efficacy and safety of pancreas transplantation concomitant with renal transplantation (SPKT) or following renal transplantation (PAKT) and the exocrine anastomosis meth...

RESUMO O objetivo do presente trabalho foi relatar um caso de leishmaniose visceral com apresentação mucosa em um cão com hiperadrenocorticismo. Um canino, macho, da raça Poodle, 11 anos de idade, foi atendido com hi...

The number of patients with a failed allograft returning to dialysis increases over time. These patients have increased morbidity and mortality compared with their transplant-naive, incident dialysis patients. The manage...

ABSTRACT Mycobacterium fortuitum mycobacteremia and arthritis were diagnosed in a Briard dog from northern California. The dog was evaluated for lameness and had a history of immunosuppressive treatment and splenectomy f...

Abstract Background Limited information is available regarding the clinical features, treatment, and prognosis of neosporosis in adult dogs. Objective Describe the clinical signs, laboratory findings, magnetic resonance ...

Renal transplantation is the best method of renal replacement therapy for patients with end-stage renal disease. On the other hand in the early or late period of transplantation, majority of patients suffer from allograf...

Acquired hemophilia A (AHA) is a rare, potentially life-threatening autoimmune bleeding disorder characterized by the development of inhibitory autoantibodies against factor VIII (FVIII). While most commonly diagnosed in...