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Abstract Infectious disease diagnostics has been transformed by metagenomic next‐generation sequencing (mNGS), an unbiased approach that detects bacteria, viruses, fungi, and parasites in a single assay. By sequencing ...

Abstract Background Social mixing studies provide crucial evidence for parameterizing mathematical models of infectious disease transmission, and their validity for use in models is dependent on their study design and ho...

Abstract The global emergence and spread of infectious diseases highlights the importance of having an easily accessible, decentralized testing modality that is adept at quickly identifying the nucleic acids present in a...

Background and AimMost infections are innocuous in most individuals, and most infectious diseases are confined to specific organs. Inborn errors of tissue-intrinsic, non-leukocytic immunity underlie some organ-specific i...

Abstract Background Empiric antimicrobial selection in orthotopic heart transplantation (OHT) is critically important as post-operative infections are a significant cause of morbidity and mortality. While variability of ...

Background The field of extracellular vesicles (EVs) has advanced considerably in recent years with new findings stemming from technical improvements in their isolation and characterization, expanding their potential as ...

Pelvic inflammatory disease (PID) is a complex multifactorial infectious disorder of the female reproductive tract, associated with severe long-term sequelae including infertility, ectopic pregnancy, and chronic pelvic p...

Abstract Background Kawasaki disease (KD) is an acute systemic vasculitis of childhood and the leading cause of acquired heart disease in children in developed countries. Infants frequently present with incomplete diseas...

This integrative review synthesizes current knowledge on the physiological responses and adaptive mechanisms of amphibians and reptiles to multiple interacting environmental stressors, with particular emphasis on synergi...

Background. Infectious mononucleosis (IM), most commonly caused by the Epstein–Barr virus (EBV), affects primarily adolescents and young adults between 15 and 24 years of age, populations with high rates of sports par...

ABSTRACT Background Mpox is a zoonotic viral disease caused by the monkeypox virus, with potential for significant morbidity across all population groups, including pregnant individuals and neonates. Pregnancy represents...

Abstract Background Bacterial diseases include any illness caused by bacteria. Bacteria are tiny microorganisms that can only be seen with a microscope. Other types of microorganisms include viruses, fungi, and some para...

Reconstructing the early spatiotemporal dynamics of emerging infectious diseases (EIDs) is essential for effective public health response but remains difficult due to reporting delays, heterogeneous surveillance systems,...

Tuberculosis (TB) is an infectious disease and one of the major causes of mortality worldwide, especially in children under the age of 15 years. Abdominal TB includes TB of bowel, peritoneum, lymph nodes, or other soli...

Serum sickness is an immune complex-mediated hypersensitivity reaction, classically manifested by the triad of fever, rash, and arthralgias. It results from the formation and deposition of antigen–antibody complexes, l...

X-linked agammaglobulinemia (XLA) is an inherited inborn error of immunity caused by low or absent Bruton tyrosine kinase activity, resulting in impaired B cell development, poor immunoglobulin production, and severe, re...

Abstract Introduction Several risk factors for progression to severe COVID-19 have been identified, but whether multiple concomitant risk factors (risk stacking) further increase risk remains unknown. We sought to ident...