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Autoimmune rheumatic diseases (ARDs), often characterized by pain, constitute a diverse group of autoimmune conditions involving inflammation-mediated injuries to bones, joints, surrounding connective tissues, and occasi...

Abstract Introduction Bone and joint infections (BJIs) are complex and difficult to eradicate, and have high relapse rates and limited oral treatment options. Tetracyclines combine favorable bone penetration, oral bioava...

Abstract Cartilage and synovium are essential tissues involved in joint-related diseases and traits, including osteoarthritis (OA), rheumatoid arthritis (RA), and human height. Although genome-wide association studies (G...

Abstract‌ Objective This finite element analysis compared the biomechanical performance of two surgical approaches for Neer Type II distal clavicle fractures: isolated locking plate fixation versus locking plate fixati...

Abstract Background This systematic and meta-analysis review aimed to evaluate the effectiveness of therapeutic exercises on the lower limbs in individuals with joint hypermobility syndrome. Main body of the abstract Thi...

Abstract Juvenile idiopathic arthritis (JIA) is an umbrella term for a group of oligo- and poly-arthritic conditions that develop before 16 years of age. While the exact pathophysiology of JIA is still unknown, both gene...

Abstract Background Low back pain and temporomandibular Dysfunction (TMD) have a coexistence in clinical practice. To find the effect of temporomandibular exercises (TME) along with conventional physiotherapy in patient...

Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency and remains underdiagnosed in Brazil due to limited knowledge of its genetic landscape. Since 2024, the Centro Nacional d...

Parabens, ubiquitous preservatives with endocrine-disrupting potential, may adversely affect mental and cardiometabolic health, but evidence in elderly populations is limited. This study aimed to explore the relationship...

ABSTRACT Objective Adjacent segment retrolisthesis is a common yet frequently overlooked complication after lumbar fusion, which may lead to reoperation. However, its risk factors, particularly those related to preoperat...

Abstract Background Ankle arthrodesis is an established procedure for end-stage ankle osteoarthritis. Besides the known limited functionality, gait and foot arch changes are accompanying pathologies, which are little inv...

Abstract Introduction Omadacycline is indicated for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. With limited real-world data, we report the clinical exp...

Abstract Background Managing ARCO stage III osteonecrosis of the femoral head (ONFH) is controversial, as surgeons choose between joint preservation and arthroplasty. While MRI provides superior assessment of lesion geom...

Abstract Background The kinematics of the wrist have been widely studied in terms of flexion/extension, radial/ulnar deviation, and the dart-throwing motion (DTM); however, the opposite dart-throwing motion (oDTM)—desp...

Materias / palabras clave: projectile injury; peripheral nerve; axillary nerve; intercostobrachial nerve; CRPS; glenohumeral joint; denervation; nerve transfer

Abstract Background Epidemiological associations between multiple metals exposure and hypertension or blood pressure remain limited and inconclusive, especially for essential metals. This investigation intended to examin...

Abstract Rheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint diseases characterized by persistent inflammation, progressive cartilage degeneration, and impaired tissue repair mechanisms. While i...

Background: Rheumatoid arthritis (RA) causes structural changes and inflammatory responses which damage the knee tissues that include the cruciate ligaments. Scientists will gain knowledge about ligament involvement in c...

ABSTRACT Background and Aims Chronic inflammation contributes to various chronic diseases, emphasizing the need for reliable biomarkers for early detection and understanding its causes. Measuring chronic inflammation pos...

Importance Tinnitus, affecting 10% to 15% of the global population, is a debilitating condition often linked to hearing loss and neurological disorders. While air pollution is a known risk factor for respiratory and card...

Objectives: To comprehensively analyse the burden of five oral diseases in China, including caries of deciduous teeth, caries of permanent teeth, periodontal diseases, edentulism, and other oral disorders; compare their ...

BackgroundChromosome 22q11.2 deletion syndrome is the most common microdeletion chromosomal anomaly. Frequent infections have been described as a major feature of immunodeficiency noted in 22qDS. Immune dysregulation is ...

Clinical research and real-world observational studies are essential for advancing the diagnosis and treatment of rare diseases, such as inborn errors of immunity/primary immune disorders (IEI/PID). To support efficient ...

Abstract Background Musculoskeletal diseases, such as Juvenile Idiopathic Arthritis (JIA), can lead to altered joint mobility and changes in gait pattern. While marker-based motion capture systems are considered the gold...