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The renin-angiotensin system (RAS) has been implicated in pulmonary hypertension and pulmonary fibrosis. In the present study, we examined the effects of maternal exposure to captopril (2.85. mg/kg/day) during late pregn...

Abstract Background Interstitial lung disease (ILD) is characterized by marked heterogeneity and an overall poor prognosis, with many patients experiencing rapid progression and high short-term mortality. Accurate early ...

IntroductionProgressive lung disease remains the leading cause of morbidity and mortality in patients with STAT3 hyper-IgE syndrome (HIES), despite optimal supportive care. Forced expiratory volume in 1 second (FEV1) is ...

ObjectiveDespite the widespread use of immune checkpoint inhibitors (ICIs) improving survival outcomes in non-small cell lung cancer (NSCLC) patients, immune-related adverse events (irAEs) triggered by ICIs have become a...

Jiaxuan Wu,1– 5,* Huohuo Zhang,1– 5,* Lan Yang,1– 5,* Jiadi Gan,1– 5 Guoqing Wang,6 Xiaolong Tang,1– 5 Jinghong Xian,1– 5 Lin Zhu,7 Yalun Li,1– 5 Weimin Li1– 5 1Department of Pulmo...

Adhesion proteins from Mycoplasma gallisepticum (MG) encoded by cytadhesion genes mgc1 and mgc2 were cloned into plasmid vectors and transformed into E. coli. Seventeen groups of specific-pathogen free (SPF), birds at fo...

Abstract Background Interstitial lung abnormalities (ILA) are radiologic findings of increased lung density or fibrosis in individuals without clinical interstitial lung disease (ILD) and are associated with increased mo...

Lung fibrosis is a severe disease with limited therapeutic options. The vascular niche is critical for lung function and fibrotic diseases, but the mechanisms by which endothelial cells (ECs) are regulated during lung in...

BackgroundCancer cell evasion of the immune response is critical to cancer development and metastases. Clinicians' ability to kickstart the immune system to target these rogue cells is an ever-growing area of research an...

Autostyly, defined by fusion of the palatoquadrate to the neurocranium and loss of the hyomandibula as a suspensory element, is a hallmark of lungfish cranial organization among sarcopterygians, yet its evolutionary orig...

Abstract Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and poses a significant threat to public health. Traditional treatments often lead to poor prognoses and tum...

IntroductionMatrix stiffening during idiopathic pulmonary fibrosis (IPF) creates a mechanically altered microenvironment that promotes fibroblast activation, yet the metabolic consequences of these mechanical cues remain...

Cu, a common essential trace element in the human body, is involved in multiple physiological and pathological processes. Cuproptosis, a recently proposed form of cell death, is triggered by Cu overload. It primarily tar...

Materias / palabras clave: HMGB1 (high mobility group box 1); lung cancer; tumor microenvironment; fatty acid; immunotherapy

Abstract Bronchopulmonary dysplasia (BPD) is a common complication among preterm neonates, with portable X-ray imaging serving as the standard diagnostic modality in neonatal intensive care units (NICUs). However, lung m...

BackgroundGranulomatous-lymphocytic interstitial lung disease (GLILD) is a noninfectious interstitial lung disorder characterized by granulomatous inflammation and lymphoid proliferation. It is most frequently identified...

Primary immune regulatory disorder (PIRD) is a subset of inborn errors of immunity (IEIs) caused by disruption of genes involved in regulating the immune response. PIRDs are predominantly characterized by dysregulated im...

IntroductionWe have previously demonstrated that intratracheal lipopolysaccharide (LPS) injection induces significant pulmonary inflammation accompanied by hippocampal microglial activation, indicative of neuroinflammati...

Multiple myeloma (MM) is a multisystem disorder where renal involvement worsens the prognosis significantly. Herein, we present two cases with an atypical clinical presentation. A 38-year-old female presented to our c...

Abstract Background Congenital malformations in domestic cats are traditionally considered uncommon; however, recent evidence suggests they may represent an underrecognized cause of neonatal mortality. Most reported anom...

Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance i...

Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems. There are no curative treatments for patients with silicos...

Abstract Background Medical oncology is a young specialty in Romania, where early-career oncologists face challenges related to training, mentorship, and research. This study explored their professional status and needs ...

A malformação adenomatóide cística fetal consiste em anomalia do desenvolvimento pulmonar, proveniente de crescimento anormal dos bronquíolos respiratórios terminais. Por tratar-se de malformação rara, nem sempre...