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Abstract Background Interstitial lung disease (ILD) is characterized by marked heterogeneity and an overall poor prognosis, with many patients experiencing rapid progression and high short-term mortality. Accurate early ...

IntroductionProgressive lung disease remains the leading cause of morbidity and mortality in patients with STAT3 hyper-IgE syndrome (HIES), despite optimal supportive care. Forced expiratory volume in 1 second (FEV1) is ...

ObjectiveDespite the widespread use of immune checkpoint inhibitors (ICIs) improving survival outcomes in non-small cell lung cancer (NSCLC) patients, immune-related adverse events (irAEs) triggered by ICIs have become a...

Jiaxuan Wu,1– 5,* Huohuo Zhang,1– 5,* Lan Yang,1– 5,* Jiadi Gan,1– 5 Guoqing Wang,6 Xiaolong Tang,1– 5 Jinghong Xian,1– 5 Lin Zhu,7 Yalun Li,1– 5 Weimin Li1– 5 1Department of Pulmo...

Abstract Background Interstitial lung abnormalities (ILA) are radiologic findings of increased lung density or fibrosis in individuals without clinical interstitial lung disease (ILD) and are associated with increased mo...

Lung fibrosis is a severe disease with limited therapeutic options. The vascular niche is critical for lung function and fibrotic diseases, but the mechanisms by which endothelial cells (ECs) are regulated during lung in...

Autostyly, defined by fusion of the palatoquadrate to the neurocranium and loss of the hyomandibula as a suspensory element, is a hallmark of lungfish cranial organization among sarcopterygians, yet its evolutionary orig...

Abstract Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and poses a significant threat to public health. Traditional treatments often lead to poor prognoses and tum...

IntroductionMatrix stiffening during idiopathic pulmonary fibrosis (IPF) creates a mechanically altered microenvironment that promotes fibroblast activation, yet the metabolic consequences of these mechanical cues remain...

Cu, a common essential trace element in the human body, is involved in multiple physiological and pathological processes. Cuproptosis, a recently proposed form of cell death, is triggered by Cu overload. It primarily tar...

Materias / palabras clave: HMGB1 (high mobility group box 1); lung cancer; tumor microenvironment; fatty acid; immunotherapy

Abstract Bronchopulmonary dysplasia (BPD) is a common complication among preterm neonates, with portable X-ray imaging serving as the standard diagnostic modality in neonatal intensive care units (NICUs). However, lung m...

BackgroundGranulomatous-lymphocytic interstitial lung disease (GLILD) is a noninfectious interstitial lung disorder characterized by granulomatous inflammation and lymphoid proliferation. It is most frequently identified...

Primary immune regulatory disorder (PIRD) is a subset of inborn errors of immunity (IEIs) caused by disruption of genes involved in regulating the immune response. PIRDs are predominantly characterized by dysregulated im...

IntroductionWe have previously demonstrated that intratracheal lipopolysaccharide (LPS) injection induces significant pulmonary inflammation accompanied by hippocampal microglial activation, indicative of neuroinflammati...

Abstract Background Congenital malformations in domestic cats are traditionally considered uncommon; however, recent evidence suggests they may represent an underrecognized cause of neonatal mortality. Most reported anom...

Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance i...

Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems. There are no curative treatments for patients with silicos...

Abstract Background Medical oncology is a young specialty in Romania, where early-career oncologists face challenges related to training, mentorship, and research. This study explored their professional status and needs ...

Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants and is characterized by aberrant late-stage lung development driven by multiple factors. Although previous studies have demonstr...

Abstract Introduction This study aimed to develop a deep learning-based system to automatically assess patient positioning compliance in chest radiographs, focusing on cervical spine visibility, scapular overlap, and cos...

We performed a single-center retrospective analysis of chronic granulomatous disease (CGD) autopsy reports to better understand causes of death, end-organ damage, and disease pathophysiology. Forty-four autopsies of CGD ...

Abstract Background The newly discovered Treg subset (CLA+ Tregs) expressing cutaneous lymphocyte-associated antigen is associated with inflammatory conditions. This study elucidated the role of CLA+ Tregs in rheumatoid ...

Abstract Acute, whole-body exposure to ionizing radiation has the potential to induce widespread injury, compromising multiple organ systems and predisposing the individual to a variety of pathologies. For medical counte...