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ABSTRACT Cancer metastasis is the leading cause of cancer‐related mortality, involving complex interactions between tumor cells and the mechanically heterogeneous tumor microenvironment. The cell nucleus serves as a ce...

ABSTRACT Epithelial and endothelial monolayers maintain homeostasis by adapting to physiological stimuli and injury through conversion processes that remain incompletely understood. Using human umbilical vein endothelial...

Mechanotransduction is a process where cells sense their surroundings and convert the physical forces in their environment into an appropriate response. Calcium plays a crucial role in the translation of such forces to b...

IntroductionOsteoarthritis (OA) is a common joint disease characterized by progressive biomechanical deterioration of cartilage tissue. This study aims to develop an explainable ensemble machine learning model capable of...

The fascia, a pervasive connective tissue network, has traditionally been studied for its structural and biomechanical roles in the human body. However, emerging evidence suggests that fascia may also play a significant ...

Notch1 is a mechanosensitive endothelial receptor that responds to vascular wall shear stress. However, data on Notch1 activity in humans remains limited, particularly regarding its role in endothelial function.

Tumor diseases pose an enormous health threat when they become malignant, as in the process of metastasis. Cancer metastasis has been extensively studied in the past, but attention has been focused primarily on the estab...

ABSTRACT Background Intervertebral disc degeneration (IVDD), a prevalent spinal disorder, is closely associated with abnormal mechanical stress. The nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplat...

Neuroinflammation is a key immunological driver of spinal sensitization and the transition from acute to chronic pain. Although mechanical interventions can reduce pain, the immuno-inflammatory mechanisms linking mechani...

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

Materias / palabras clave: biological condensates, coacervates, mechanobiology, mechanotransduction, membrane transport, protein structure and dynamics; Technology: Chemical technology: Biotechnology

Materias / palabras clave: mechanobiology, biomechanics, biomedical engineering, biophysics, translational medicine, mechanotransduction; Medicine: Medicine (General): Medical technology