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Mediator 17 (MED17) is part of the head of the Mediator complex, which regulates transcription initiation indifferent eukaryotic organisms, including plants. We have previously characterized MED17 roles in Arabidopsispla...

In this paper, I am attempting to throw into relief significant aspects of the function of television debate as a public sphere. My working assumption is that public dialogue, including its televised versions, involves p...

Abstract Fungal histone methylation modification (HMM) includes methylation and demethylation at the histone lysine/arginine residues, which are catalyzed by the methyltransferases (HMTs) and demethylases (HDMs) of histo...

Understanding why college students consider changing majors is critical for improving academic fit and supporting career development in higher education. Drawing on a mixed-methods design, this study examines how social ...

Abstract Cerebrovascular regulatory capacity is essential for maintaining brain stability. Most previous studies have focused on middle-aged and elderly populations, where regulation depends on vasodilation with reduced ...

Abstract Background Lupus nephritis (LN) is driven by podocyte pyroptosis triggered by NLRP3 inflammasome activation, yet the dual regulatory mechanisms—transcriptional control by the AP-1 complex (c-JUN/c-FOS heterodi...

BackgroundChronic kidney disease (CKD) is a major global health burden with substantial morbidity and mortality. Proteinuria is strongly associated with adverse renal outcomes, and podocyte pyroptosis is increasingly rec...

Abstract DNA double-strand break (DSB) represents the most severe form of DNA damage, and both defective and hyperactive repair can compromise genome stability. It is known that blue light promotes DSB repair by cryptoch...

The provision of T cell co-stimulation via members of the TNFR super-family, including OX40 (CD134) and 4-1BB (CD137), provides critical signals that promote T cell survival and differentiation. Recent studies have demon...

Background: The progression of pulpitis is strongly affected by the fate of dental pulp cells, with their modes of cell death determining whether inflammation resolves or leads to irreversible necrosis. Cuproptosis, a co...

The menstrual cycle affects many aspects of female physiology, from the immune system to behavioral and emotional regulation. It is unclear however if these physiological changes are reflected in everyday, naturalistic l...

Abstract The complexity of student social adaptability development mechanisms in the context of physical education reform urgently requires in-depth exploration. Grounded in self-determination theory as the primary theor...

Abstract Metastasis is the leading cause of cancer-related deaths. Understanding the molecular mechanism of tumor metastasis is of great significance to cancer research. However, the molecular diagnosis and treatment of ...

Abstract Background The insular cortex (IC), a pivotal hub for pain signal integration, projects extensively to the thalamus. However, the functional role of its specific projection to the central medial thalamic nucleus...

BackgroundParenting stress evokes harsh discipline and induces internalizing problems in children and adolescents. To test this hypothesis, this study examined the potential mediating role of harsh discipline in the asso...

Cet article explore les liens entre les gouvernements et les médias en Amérique du Sud entre 2002 et 2019 en s’appuyant sur les cas de l’Argentine, de la Bolivie, du Brésil, de l’Équateur et de l’Uruguay. Les...

Abstract Background Non-suicidal self-injury (NSSI) poses a serious threat to adolescents’ physical and mental health. This study aims to systematically examine the network structure of the relationship between adolesc...

Abstract Substance use among adolescents is a serious social problem that may be related to emotional dependence, attachment styles and difficulties in emotional regulation. Thus, the objectives of this study were to ana...

Abstract Background Chronic neuropathic pain is frequently accompanied by anxiety and depression, yet the cortical circuit mechanisms underlying this comorbidity remain unclear. The medial orbitofrontal cortex (mOFC) is ...

Adolescents encounter large volumes of non-core (i.e., nutritionally poor and unhealthy) food messages on social media. The relationship between these messages and eating is a product of both the volume of exposure to th...

IntroductionCognitive reappraisal is widely regarded as adaptive; however, strategies that impose control to reduce unpleasant emotion may involve tradeoffs when individuals encounter personally meaningful reminders of p...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

N6-methyladenosine (m6A) is a major post-transcriptional RNA modification, and the demethylase ALKBH5 has emerged as a versatile but highly context-dependent regulator of RNA fate. This review integrates current evidence...

While 60 countries have expanded legal abortion access over the past three decades, implementation gaps persist, necessitating innovative approaches beyond conventional law reform. This paper examines the concept of mens...