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ABSTRACT Proton exchange membrane water electrolysis (PEMWE) is a compelling route for sustainable green hydrogen production. Yet Ir‐based oxygen evolution reaction (OER) catalysts suffer from a persistent trade‐off ...

Vascular calcification arises from osteogenic transdifferentiation of vascular smooth muscle cells (VSMC) driven by disordered calcium signaling. Sarcoplasmic/ER calcium ATPase 2 (SERCA2) maintains intracellular calcium ...

ABSTRACT Platelets are crucial to the development of thrombosis and coagulation abnormalities in sepsis, but the mechanisms by which they contribute to these pathological processes are not fully understood. Here, we iden...

The electrical properties of electrodeposited zinc‐copper‐telluride (ZnCuTe) nanowires embedded in polycarbonate track‐etch membrane (Whatman) having pore‐diameters of 200, 100 and 50nm have been studied and repo...

Recent studies from our laboratory provided evidence that part of the carcinogenic effects of ethanol consumption might be related to its in situ metabolism at cytosolic and microsomal levels, to the mutagen acetaldehyde...

M6a is a neuronal membrane glycoprotein whose expression diminishes during chronic stress. M6a overexpression in rat primary hippocampal neurons induces the formation of filopodial protrusions that could be spine precurs...

Electrospinning is a technique that allows the preparation of nanofibers from various materials. Chitosan is a natural and abundant easily obtained polymer, which, in addition to those features, proved to be biocompatibl...

Protein misfolding and aggregation into amyloid fibrils (AFs) are critical issues associated with protein stability during food processing and storage, as well as with pathological damage in organisms. Hen egg white lyso...

The intrinsic pathway of apoptosis is activated by signals of cellu-lar stress and regulated at the mitochondrial level. Such regulationis carried out by members of the Bcl-2 protein family (B leukemiacell lymphoma 2). P...

The tight junction regulates the paracellular passage of solutes and water. It is primarily constituted by the family of claudins which assemble to huge multimers and basically seal the paracellular cleft. Certain claudi...

Developing cost-effective and highly durable electrocatalysts to overcome the sluggish kinetics of the oxygen reduction reaction (ORR) is critical for the promotion of proton exchange membrane fuel cells (PEMFCs). In thi...

Abstract Background Sickle cell retinopathy (SCR) is a well-documented and potentially vision-threatening presentation of sickle cell disease (SCD). In this article, we provide a comprehensive review of the management op...

Water homeostasis during fetal development is of crucial physiologic importance. The successful formation and development of the placenta is critical to maintain normal fetal growth and homeostasis. The expression of sev...

The host cell recognition and removal of invading pathogens are crucial for the control of microbial infections. However, several microorganisms have developed mechanisms that allow them to survive and replicate intracel...

Background The field of extracellular vesicles (EVs) has advanced considerably in recent years with new findings stemming from technical improvements in their isolation and characterization, expanding their potential as ...

mRNA vaccines emerged as a leading vaccine technology during the COVID-19 pandemic. However, their sustained protective efficacies were limited by relatively short-lived antibody responses and the emergence of SARS-CoV-2...

It is known that bradykinin (BK) B2 receptor (B2R) is expressed in the collecting duct (CD) cells of the newborn rat kidney, but little is known about its role during early postnatal life. Therefore, we hypothesize that ...

Ureteral stent-associated urinary tract infections (UTIs) remain a significant clinical challenge, primarily due to bacterial adhesion and biofilm formation. To address this, we engineered a multifunctional antibacterial...

Abstract Background Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the ...

Endocrine disruptors (EDs) are exogenous substances or xenoestrogens natural or synthetic, capable of interacting with different systems and altering their normal hormonal regulation, being the reproductive system one of...

Abstract Ocular neovascular and neurodegenerative diseases, such as diabetic retinopathy and age-related macular degeneration, are characterized by abnormal angiogenesis, vascular leakage, and progressive retinal neurode...

Abstract Background Laccases (LACs) are multicopper oxidases that play vital roles in lignin polymerization, cell wall formation, and various stress responses in plants. Despite their importance, genome-wide investigatio...

The Nck adaptor protein recruits cytosolic effectors such as N-WASP that induce localized actin polymerization. Experimental aggregation of Nck SH3 domains at the membrane induces actin comet tails-dynamic, elongated fil...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...