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ObjectivesMevalonate kinase deficiency (MKD) is a metabolic disorder caused by a block in the mevalonate pathway, leading to impaired synthesis of cholesterol and isoprenoids. Clinically, MKD presents with recurrent infl...

Abstract COVID-19, caused by SARS-CoV-2, is increasingly recognized as a systemic disorder with inflammation, endothelial dysfunction, and metabolic perturbations. This study aimed to characterize metabolic changes in CO...

Immune responses and inflammation are not stand-alone processes linearly regulated by the canonical signaling pathways but complex systems biology events, which are deeply rooted in the metabolic state of cells and dynam...

Aortic diseases (aortic aneurysm, aortic dissection, atherosclerosis) represent a substantial clinical and economic burden due to the lack of effective early diagnostic tools and mechanism-based therapies. Metabolomics, ...

Transitioning from petrochemical–derived products to sustainable bioprocesses requires low–cost inocula and robust operational strategies. Yet, the undefined mixed inocula (UMI) tunability from landfill ecosystems fo...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

BackgroundMetabolic syndrome (MetS) affects approximately 1.54 billion adults worldwide and is characterized by central obesity, insulin resistance, hypertension, and dyslipidemia. Chronic low-grade inflammation is cen...

Abstract Background Current evidence regarding the role of Metabolic Syndrome (MetS) and its components in Calcific Aortic Valve Stenosis (CAVS) remains limited and inconsistent. To elucidate the causal relationship and ...

Materias / palabras clave: adiposity; chronic diseases; MASH; MASLD; metabolic syndrome; obesity

Abstract Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy with limited therapeutic options in the relapsed or refractory setting. Selinexor, a selective inhibitor of nuclear export targeting X...

Tetrachlorobisphenol A (TCBPA), a widely used chemical on material modification and flame retardant synthesis, bioaccumulates through the food chain and presents significant health concerns. However, the long-term effect...

Abstract Background Heart failure with preserved ejection fraction (HFpEF) disproportionately affects elderly women and is closely associated with central obesity and metabolic dysfunction. Although sodium-glucose co-tra...

Abstract Objective This study aimed to investigate the independent predictive value of the uric acid-to-HDL-C ratio (UHR) for metabolic syndrome (MS) in the elderly, develop an optimized diagnostic model, and assess whet...

Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...

Abstract Background Understanding the association between birds, zoonotic infections, and urban environments is increasingly important due to industrialization and emerging zoonoses. Investigating the diversity, structur...

IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...

Abstract Background This study investigates the impact of chronic hepatitis B virus infection on triglyceride metabolism through alterations in the gut microbiome, using a faecal microbiota transplantation (FMT) mouse mo...

IntroductionAlthough immune responses to Bacillus Calmette–Guérin (BCG) vaccination and susceptibility to mycobacterial infection vary across individuals, the underlying cellular mechanisms regulating this heterogenei...

Gastrodia elata Blume, a traditional medicinal plant, the dynamic metabolic changes and the mechanisms underlying the accumulation of medicinal components remain poorly understood during its key developmental stages (tub...

Metabolic alteration has emerged as a hallmark of cancer, reshaping cellular energetics and biosynthetic pathways through enzyme denaturation, mutations, acidic pH, and hypoxia to sustain uncontrolled proliferation. Unde...

Antipsychotic (AP) medications are used to treat schizophrenia and a number off-label conditions. Although effective in reducing psychoses these drugs increase the risk of developing cardiometabolic disease, and are one ...

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...

An emerging body of evidence has highlighted the complex interplay among obesity, insulin resistance, and the gut microbiota. This observational study aimed to evaluate differences in intestinal microbiome profiles betwe...

Plastic pollution is a global crisis, with polystyrene (PS) among the most recalcitrant polymers owing to its stable aromatic structure and resistance to natural degradation. Although insect larvae such as mealworms and ...