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Abstract Minimal hepatic encephalopathy (MHE) is a cognitive, motor, and sleep-related disorder resulting from liver impairment, often linked to elevated ammonia levels. Zinc deficiency is common in patients with cirrhos...

Allergic rhinitis (AR), asthma, and their combined allergic rhinitis and asthma syndrome (CARAS) frequently coexist. However, the underlying pathophysiological and metabolic mechanisms, as well as reliable diagnostic dif...

Crabapple (Malus prunifolia (Willd.) Borkh) is valued for its ornamental appearance, effectiveness as a rootstock, and rich nutritional profile. However, the flavor profile and metabolite composition are poorly character...

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The vast majority of the mortality is due to pr...

ABSTRACT Background The muscle tissue of dairy cows is a site of β‐hydroxybutyrate (BHBA) metabolism. The mechanisms underlying the changes in proteins and metabolites in the muscle tissue of cows with ketosis remain ...

Parkinson’s disease (PD) is characterized by profound metabolic disturbances in the brain, yet how these alterations vary across brain regions and respond to neuroprotective intervention remains poorly understood. Here...

Abstract Background Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, and its diagnosis remains controversial due to heterogeneous phenotypes and varying diagnostic criteria. Insulin resista...

Aortic diseases (aortic aneurysm, aortic dissection, atherosclerosis) represent a substantial clinical and economic burden due to the lack of effective early diagnostic tools and mechanism-based therapies. Metabolomics, ...

Abstract The liquid chromatography mass spectrometry (LC-MS)-based metabolomic and lipidomic methodology has great sensitivity and can describe the fingerprint of metabolites and lipids in pork and beef. This approach is...

ObjectivePolycystic ovary syndrome (PCOS) is a complex endocrine disorder. In this study, we characterize serum bile acids (BAs) metabolic profiles in PCOS patients using targeted metabolomics and investigated their corr...

Gitelman syndrome (GS) is a rare hereditary kidney disorder characterized by electrolyte abnormalities. However, its systemic manifestations, such as growth retardation, suggest broader metabolic disturbances. To investi...

ABSTRACT Fast-growing broilers are prone to pulmonary hypertension, which is the main cause of death in broilers with ascites syndrome (AS). The underlying mechanisms of AS and the role of metabolomics changes involved i...

Abstract Background Timely and accurate pregnancy detection in the dairy animals is essential for minimizing calving intervals to accelerate reproductive turnover and increase milk production from livestock farming. Urin...

IntroductionGastrodia elata f. glauca represents a superior cultivar of G. elata with considerable commercial value and broad market acceptance. The growth of its tubers and the accumulation of bioactive secondary metabo...

Background and ObjectiveDifferentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is clinically difficult, especially when patients are seronegative for anti–aquaporin-4 immunoglobulin...

ABSTRACT A systems biology approach was used to characterize Monotropa uniflora, a nonhotosynthetic, myco‐heterotrophic plant. In contrast to autotrophic plants, myco‐heterotrophic plants obtain carbon and other nutr...

Abstract Background Viral infections of tomato plants present a significant threat to tomato production and yield. Mixed viral infections are common in field-grown tomatoes and are known to exacerbate disease symptoms; h...

Abstract Background Feline pancreatic lipase immunoreactivity (fPLI) is commonly used to diagnose pancreatitis in cats (FP). Untargeted metabolomics has been extensively applied in human and veterinary medicine, but no m...

Background: Hyperuricemia (HUA) is caused by purine metabolism dysregulation or impaired uric acid (UA) excretion. Its global prevalence has increased, particularly among younger populations. Edible dock protein (EDP) po...

Abstract Backgrounds Acute primary angle-closure glaucoma (APACG) and chronic primary angle-closure glaucoma (CPACG) exhibit distinct clinical features, yet the molecular mechanisms underlying their differing progression...

Abstract Diminished ovarian reserve (DOR) lacks strong plasma biomarkers, and recent studies have implicated lipid remodeling in its pathophysiology. In our previous study, we noted elevated circulating levels of semapho...

Abstract Fetal mortality significantly impacts reproductive efficiency in sheep, with approximately 30% of fetuses failing to survive until lambing. In multifetal gestation, partial litter loss (PLL) occurs in 28% to 37%...

Background Coal seams exhibit the extensive distribution of a variety of indigenous functional microorganisms. Among these, some archaea enable methane metabolism using CO2 as a substrate, providing the potential for the...

Abstract With rapid advances in meat science in recent decades, changes in meat quality during the pre-slaughter phase of muscle growth and the post-slaughter process from muscle to meat have been investigated. Commonly ...