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Tumor metastasis is the leading cause of mortality in patients with malignant cancers, and the establishment of the pre-metastatic niche (PMN) is recognized as a pivotal step in this process. With growing insight into th...

Abstract Background NEDD8 ultimate buster 1 is an interferon-inducible tumor suppressor increasingly recognized as a prognostic biomarker in breast cancer. Low cytoplasmic expression correlates with aggressive disease, y...

Abstract Testicular cancer is the most common malignancy in young men, and treatment options for metastatic or refractory disease remain limited. Chromatin remodeling plays a critical role in tumorigenesis, yet its contr...

Abeer Abdulhadi Alhuthali,1 Abdullah Alshammari,2 Athar Yosuf Jaha,2 Alaa Shahbar,2 Lama Mohammed Almilaibi,3 Reem Saeed Alwadie,2 Alanoud Naher Alghanmi,3 Manal Aljohani,4 Abdullah F Alharthi,5 Mohammed Alnuhait5 1Depar...

Abstract First-line treatment options for patients with metastatic hormone-sensitive prostate cancer (HSPC) are divided into two groups: androgen receptor signaling inhibitor (ARSI)-based doublet therapy and triplet ther...

BackgroundRenal cell carcinoma (RCC) is the most common kidney cancer in adults. The advent of immune checkpoint inhibitors (ICIs), particularly in combination with tyrosine kinase inhibitors (TKIs), has significantly im...

Abstract Epithelial-to-mesenchymal transition (EMT) is a complex and dynamic cellular process during which epithelial cells lose their polarity and cell adhesion capabilities and subsequently express mesenchymal stem cel...

Introduction Bone metastasis in breast cancer patients can lead to poor quality of life and cause significant morbidity. First-line treatments for bone metastases include bone modifying agents that inhibit osteoclast act...

HER2-low breast cancer, defined as immunohistochemistry (IHC) 1+ or 2+ with negative in situ hybridization (ISH), has emerged as a clinically relevant therapeutic subgroup. We report the case of a 40-year-old woman with ...

Abstract Immune checkpoint inhibitors (ICI) have transformed the treatment of metastatic malignancies, yet only 20–40% of unselected patients benefit. Peripheral blood could offer a minimally invasive and dynamic sourc...

BackgroundAbdominal primary Ewing sarcoma (ES) is extremely rare and carries a dismal prognosis when metastatic. First-line therapy typically involves multi-agent regimens like VDC/IE, with irinotecan-based combinations ...

In this paper we investigated whether protein kinase C (PKC) b1 and PKCe, members of the classical and novel PKC family respectively, induce phenotypic alterations that could be associated with tumor progression and meta...

Abstract Background Colorectal cancer (CRC) is frequently associated with metastasis, resulting in high mortality rates. Platelets are known to play a crucial role in the metastatic cascade influencing tumor microenviron...

Abstract This study aimed to evaluate the cost-effectiveness of Penpulimab versus placebo in treating metastatic squamous non-small cell lung cancer (NSCLC) from the perspective of Chinese payers. A three-state Markov mo...

Abstract Objectives Gastrointestinal neuroendocrine neoplasms (GI-NENs) exhibit heterogeneity in biological behavior, making it difficult to predict prognosis. We established the P Grade based on 68Ga-DOTANOC and 18F-FDG...

Background: Melanoma represents a highly aggressive and metastatic form of malignant skin cancer. that remains challenging to treat clinically. Tumor cells often reprogram nicotinamide adenine dinucleotide (NAD⁺) metab...

BackgroundSolid pseudopapillary tumors (SPTs) of the pancreas are rare, low-grade malignancies that generally have favorable outcomes when diagnosed at an early stage and can be resected. However, treatment options for p...

Abstract Purpose Patients with nasopharyngeal carcinoma (NPC) exhibiting persistent EBV DNA positivity throughout treatment (a “D-D-D” trajectory) represent a high-risk group with undefined management strategies. Thi...

Abstract The phase 3 COMPASSION-16 trial demonstrates significant progression-free survival (PFS) and overall survival (OS) benefits with cadonilimab plus standard therapy in patients with persistent, recurrent, or metas...

Abstract Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease...

Abstract Background Cervicovaginal microbiota dysbiosis has been implicated in the progression of cervical cancer. Recent studies have reported an increased abundance of Porphyromonas species in the vaginal microbiota of...

Abstract Background The tumor microenvironment of oropharyngeal squamous cell carcinoma (OPSCC) harbors diverse immune cell populations that influence tumor progression and patient outcome. Materials In 102 surgically tr...

Emmanuel Ifeanyi Obeagu1– 3 1Division of Haematology, Department of Biomedical and Laboratory Science, Africa University Mutare, Mutare, Zimbabwe; 2Department of Molecular Medicine and Haematology, School of Pathology,...