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The composition of the upper respiratory tract (URT) microbiota is shaped by both anatomical niches and host immune defenses. Older adults (>65 years) are at greatest risk of acquiring severe URT infections. However, ver...

Background: Chronic dacryocystitis, characterized by persistent inflammation and infection of the lacrimal sac and nasolacrimal duct, is a prevalent cause of ocular morbidity, particularly in rural India. Delayed diagnos...

Background: Febrile illness in pediatric populations often poses a diagnostic challenge due to overlapping clinical features across various etiologies. While respiratory infections are common, urinary tract infections (U...

Bacterial biofilm are complex microbial communities covered by a matrix of extracellular polymeric substances, which develops when a community of microorganisms irreversibly adheres to a living or inert surface. This str...

ObjectiveTo provide data support for infectious mechanism and microecological intervention strategies， the structural and functional alterations of the gut microbiota in patients with norovirus associated diarrhea was ...

Next-generation metagenomic sequencing (mNGS) enables the direct and unbiased detection of pathogens from clinical samples, overcoming the limitations of standard methods. It is particularly valuable in immunocompromised...

Introduction: Cancer patients often come across infections, which disturb their treatment regimen and raise the chances for serious complications. Aim of Study: To study the microbiological profile of infections and ant...

Abstract Background Foreign body aspiration (FBA) may be complicated by secondary respiratory tract infection. The spectrum of pathogens associated with FBA in China remains poorly described. This study aimed to obtain c...

The host cell recognition and removal of invading pathogens are crucial for the control of microbial infections. However, several microorganisms have developed mechanisms that allow them to survive and replicate intracel...

Genetic alteration of the genes of cytoskeletal regulatory proteins (e.g., actin-related protein complex-1 [ARPC1]) results in severe immune and hematological defects. ARPC1B deficiency (ARPC1BD) is an immune-actinopathy...

The characteristic oral environment – with its dynamic clearance, moisture, microbial load, and inflammatory potential – makes oral diseases highly prevalent and therapeutically challenging. Metal-organic frameworks ...

Abstract Chronic granulomatous disease (CGD) is an inherited immunodeficiency characterized by impaired phagocytic function due to defects in the NADPH oxidase complex. This enzymatic deficiency compromises the productio...

Introduction: Ureteral Double J (DJ) stents are commonly used in urology to ensure urinary drainage. However, prolonged indwelling time increases the risk of bacterial colonisation and biofilm formation, which can lead t...

X-linked agammaglobulinemia (XLA) is an inherited inborn error of immunity caused by low or absent Bruton tyrosine kinase activity, resulting in impaired B cell development, poor immunoglobulin production, and severe, re...

Surface functionalization of cellulose nanocrystals (CNCs) is commonly used to improve their dispersibility, functionality, and performance across diverse applications. However, the potential biosafety risks of these mod...

Abstract Background Metagenomic next-generation sequencing (mNGS) emerging as a standout in the clinical setting. In this study, we harnessed the power of mNGS to explore the pathogenic spectrum and temporal variations i...

Bone infection is a severe disease caused by microbial invasion of bone tissue, characterized by inflammatory responses, bone destruction, and impaired repair. Its high recurrence rate and refractory nature have posed si...

The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS2) affected the geriatric population. Among research models, Golden Syrian hamsters (GSH) are one of the most representative to study SARS2 pathogenesi...

Abstract Callithrix comprises primates popularly known as marmosets. In the city of Rio de Janeiro, the occurrence of a hybrid form of invasive species prevails. These animals, treated here as Callithrix spp., host sever...

Modern animal and crop production practices are associated with the regular use of antimicrobials, potentially increasing selection pressure on bacteria to become resistant. Alternative approaches are needed in order to ...

Otitis media is a prevalent condition affecting individuals of all ages, often accompanied by symptoms such as ear pain, fluid accumulation, and possible hearing loss. Bacterial infections are among the leading causes, w...

Background22q11.2 deletion syndrome (22q11.2DS, also known as DiGeorge) affects 1/2,150 individuals. The deletion results in variable clinical phenotypes: thymic hypoplasia or aplasia, hypoparathyroidism, cardiac defects...

Background and objectives: Biofilms have a major medical significance as they decrease susceptibility to antimicrobial agents. The decreased susceptibility to microbial agents within a biofilm arises from multiple factor...

Abstract Background The vaginal and penile coronal sulcus microbiome influence reproductive health outcomes and susceptibility to multiple sexually transmitted infections including HIV. There is evidence that genital bac...