Buscar recursos académicos

Our understanding of the synthesis and remodeling of mitochondrial phospholipids remains incomplete. Two isoforms of glycerol-3-phosphate acyltransferase (GPAT1 and 2) and two isoforms of acylglycerol-3-phosphate acyltra...

ABSTRACT A total of 80 samples were collected to analyze the mitochondrial DNA (mtDNA) and Y chromosome genetic diversity of two main Portuguese Lidia bovine populations and clarify their genetic relationships with Spani...

Chronic pain is a significant global health burden often resistant to conventional analgesics. Evidence implicates that mitochondrial dysfunction is not only a cellular consequence of injury, but also a fundamental drive...

Abstract Freshwater adaptation from marine ancestors represents a major ecological transition in teleost evolution, yet its genomic basis remains poorly understood. The genus Brachirus is predominantly marine, although a...

Abstract Background An in-depth analysis was conducted on the mitochondrial genomes of three newly introduced Terebelliformia species (Amaeana sp., Terebellides sp.A and Terebellides sp.B), focusing on their genomic feat...

Macrophage functional plasticity is intrinsically linked to metabolic reprogramming, including mitochondrial function, substrate utilization, and redox signaling. In response to hypoxia, infection, or tissue injury, macr...

Mitochondrial dysfunction is a convergent hallmark of biological aging and a mechanistically attractive target for gerotherapeutic development. Yet translation of mitochondria-focused interventions has been limited by pa...

Mitochondria are vital for maintaining cellular homeostasis. However, mitochondrial damage is evident in patients with chronic hepatitis B (CHB). The role of mitochondrial dysfunction in the persistence of viral replicat...

Aerobic exercise training can increase skeletal muscle mitochondrial content. Supine exercise training with legs above the heart potentially augments these increases. However, the impact of supine exercise training on mi...

Materias / palabras clave: mitochondria-organelle interactions, mitochondria-nuclear crosstalk, mitochondrial disease, mitochondrial dynamics, mitochondrial physiology, mitochondrial genetics; Science: Biology (General); Medicine

Li Tao,1,2,* Meiling Tai,3,* Zhuang Zhou,3 Zhenwen Chen,1 Rongjinlei Zhang,1 Yuanlong Ge,1 Zhenyu Ju1 1Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative...

BackgroundObesity is a major risk factor for lipotoxic cardiomyopathy, a process involving lipid metabolism disorders, inflammatory responses, and mitochondrial dysfunction. Salvia miltiorrhiza (Danshen), a traditional C...

Type 2 diabetes mellitus (T2D) features chronic low-grade inflammation in white adipose tissue (WAT), where adipocytes and innate immune cells engage in immunometabolic crosstalk. Mitochondrial damage-associated molecula...

A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for ...

Bangle belongs to the ginger family and has anti-inflammatory properties; however, its efficacy against skeletal muscle atrophy in ulcerative colitis (UC) remains unexplored. This study investigated the effects of Bangle...

The increasing prevalence of artificial light sources has rendered blue light (BL) a novel environmental metabolic disruptor. This study aimed to investigate the potential effects of BL exposure on mitochondrial function...

Dapagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor widely used for the treatment of diabetes, has been consistently associated with cardiovascular protection, including attenuation of ischemia/reperfusio...

Background: Spinal cord injury (SCI) has emerged as a major challenge to global public health due to its low recovery rate and high disability rate, making the development of novel therapeutic approaches imperative. Mese...

Immune responses and inflammation are not stand-alone processes linearly regulated by the canonical signaling pathways but complex systems biology events, which are deeply rooted in the metabolic state of cells and dynam...

ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contribut...

BackgroundEndometriosis is a complex gynaecological disorder that affects 10%–15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction...

Exposure to ambient air particulate matter (PM) is associated with increased cardiorespiratory morbidity and mortality. In this context, alveolar macrophages exhibit proinflammatory and oxidative responses as a result of...

Yue Hu,1,2 Peichen Xie,2 Jialin Li,2 Rui Liu,2 Haotong Wang,2 Zhicheng Wang,2 Chunyan Liu1 1Department of Radiology, The Second Hospital of Jilin University, Changchun, People’s Republic of China; 2NHC Key Laboratory o...

IntroductionLung cancer remains the leading cause of cancer-related mortality worldwide. Drug resistance is a major limitation of current therapies, prompting the search for new treatment strategies. Lung tumors frequent...