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Red blood cells (RBCs), formerly viewed as mere oxygen transporters, are now acknowledged as dynamic biological entities with intricate molecular characteristics which impact their deformability, lifespan, and interactio...

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovial inflammation, progressive cartilage destruction, and bone erosion. Although there have been significant improvements in the use of conventio...

Materias / palabras clave: cancer metabolism; cancer therapeutics; drug discovery; precision medicine; targeted therapy

Materias / palabras clave: cancer therapy; immunogenic cell death; protein kinase inhibitors; signaling pathway; targeted therapy

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that plays a pivotal role in DNA repair and the maintenance of genomic stability. The discovery of synthetic lethality in tumors with homologous recombination...

Cardiovascular disease (CVD) represents a significant global public health challenge, with its high incidence and mortality rates imposing a substantial socioeconomic burden. Tribbles family proteins (TRIB1, TRIB2, and T...

Chemotherapy-induced gastrointestinal dysfunction (CIGD) is a multifactorial clinical syndrome that substantially limits treatment tolerance, continuity, and quality of life in patients with cancer. Although targeted the...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

Photodynamic priming (PDP), a collateral effect of photodynamic therapy, can transiently alter the tumor microenvironment (TME) beyond the cytotoxic zone. Studies have demonstrated that PDP increases tumor permeability a...

Targeted B-cell depletion via the anti-CD20 monoclonal antibody rituximab fundamentally altered the therapeutic algorithm for rheumatoid arthritis (RA). Despite its clinical entrenchment, approximately 40% of patients ex...

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by heterogeneity in its genetic, epigenetic, and environmental etiologies, posing significant challenges for therapeutic development...

Abstract Atherosclerosis (AS) is a leading cause of cardiovascular and cerebrovascular disease and is driven by lipid accumulation and chronic inflammation within arterial plaques. Foam cells play a central role in plaqu...

Resumen: La leucemia mieloide aguda es una neoplasia hematológica clonal y heterogénea, es la leucemia más frecuente en adultos, con una incidencia global cercana a 4 casos por 100 000 habitantes/año y un marcado inc...

Yu Zhao,1,* Luting Wang,2,3,* Shengrui Zhu,4 Rui Feng,5 Wei Zhang1 1Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzho...

BackgroundBockenheimer disease is a rare subtype of venous malformations that involves all tissue planes of an upper extremity. This condition progresses throughout life and may cause pain, swelling, hematologic complica...

The rising concern of antimicrobial resistance, coupled with the continually challenging management of complicated diseases such as cancer, has provided momentum toward precision molecular medicine. This review provides ...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency belonging to the spectrum of common variable immunodeficiency disorders, frequently associated with immune dysregulation, autoimmun...

Abstract Ocular neovascular and neurodegenerative diseases, such as diabetic retinopathy and age-related macular degeneration, are characterized by abnormal angiogenesis, vascular leakage, and progressive retinal neurode...

We report a rare case of 32-year-old female with malignant reninoma complicated by pulmonary metastasis and ATRX mutation (p.G1964*, VAF 23.73%), initially misdiagnosed as renal pelvic carcinoma and treated with radical ...

Tamoxifen is a standard endocrine therapy for estrogen receptor positive breast cancer patients. Despite its success,development of resistance mechanisms is still a serious clinical problem. Deregulation of survival sign...

BackgroundPrimary diffuse leptomeningeal melanocytosis (PDLM) is a rare central nervous system neoplasm. Diagnosis is challenging in amelanotic variants because they lack the characteristic T1 hyperintensity on magnetic ...

ABSTRACT Background Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments—including surgery, ch...

ABSTRACT Background and Aims The Charcot–Marie–Tooth disease (CMT) comprises genetically diverse motor and sensory neuropathies. This study aims to conduct a comprehensive investigation into the current academic and ...