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Abstract Background Cardiometabolic multimorbidity (CMM) leads to adverse health outcomes. Based on data from the China Health and Retirement Longitudinal Study (CHARLS), we aimed to explore the cumulative exposure and d...

Abstract Background Multimorbidity, defined as the coexistence of at least two chronic diseases in an individual, exhibits spatial heterogeneity in its association with lifestyle factors across different climatic zones. ...

Abstract Background Cardiometabolic multimorbidity (CMM) poses a growing burden on aging populations. Small dense low-density lipoprotein cholesterol (sdLDL-C) is a key atherogenic particle, practically estimated by the ...

BackgroundIn China, which has the world’s largest and one of the fastest-aging populations, multimorbidity has become a major public health challenge. Older individuals with multiple chronic conditions experience poor ...

Xianhui Ran,1,* Zhiyuan Fan,1,* Na Wang,1,* Tianyi Zhao,1 Hui Li,1 Xiao Liu,2 Enying Gong,3 Shuanghua Xie,4 Beiyao Gao,5 Lan An,6 Gang Chen,1 Xiao Ma,1,7 Chen Wang3,7 1Health Checkup Center, China...

Abstract Background A increase in average life expectancy leads us to an older population with multimorbidity. Understanding their self-care needs is essential for a response that promotes self-care with better health ou...

Abstract Background Chronic inflammatory disease is responsible for huge and increasing global mortality and morbidity. Unregulated inflammatory cells, including neutrophils and macrophages, are major drivers of chronic ...

PurposeThe relationship among stigma, medication literacy and medication adherence in patients with multimorbidity is limited. This study was to explore the relationships among medication literacy, stigma, and medication...

Abstract There is a growing body of research on disease clusters in multimorbidity. Here we systematically review clustering methodologies and perform a meta-analysis of disease cluster stability across the literature, s...

Abstract Background Multiple inflammatory markers are central determinants of insulin resistance and cardiovascular inflammation, closely associated with cardiometabolic multimorbidity (CMM). However, the evidence regard...

Abstract Background Medication management at hospital discharge is particularly complex for older patients with multimorbidity, with additional communication challenges arising from both patient and healthcare-related fa...

Background Social relationships are associated with mortality and chronic conditions. However, little is known about the effects of social relationship satisfaction on multiple chronic conditions (multimorbidity).Aims To...

Materias / palabras clave: Medicine

Materias / palabras clave: multimorbidity, comorbidity, multiple chronic conditions; Medicine

IntroductionWhilst individually rare, affecting only a small percentage of the population, rare diseases as a whole impact around 6% of the global population (with this number likely an underestimate). Rare diseases are ...

Materias / palabras clave: handgrip strength; multimorbidity; muscle function; musculoskeletal aging; osteoarthritis; physical activity

Abstract Background Hospital rehospitalizations within 30 days represent a burden for patients and the healthcare system. Improving the care during the hospital discharge period could decrease the risk of avoidable reho...

Abstract Osteoporotic fractures (OPF) and hypertension frequently co-occur in older adults, yet comprehensive datasets integrating clinical, pharmacological, and longitudinal outcome data remain scarce. We describe a lon...

Abstract Background Healthy ageing encompasses maintaining optimal physical, psychological, social, and cognitive well-being across the lifespan. While age-specific needs are widely acknowledged, many studies aggregate a...

Abstract Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. Here, to investigate strategies that alleviate mitochondrial dysfunction, we first generate ...

Jiaxuan Wu,1– 5,* Huohuo Zhang,1– 5,* Lan Yang,1– 5,* Jiadi Gan,1– 5 Guoqing Wang,6 Xiaolong Tang,1– 5 Jinghong Xian,1– 5 Lin Zhu,7 Yalun Li,1– 5 Weimin Li1– 5 1Department of Pulmo...

Despite widespread rollout of dolutegravir-based (DTG) antiretroviral therapy (ART) in East Africa, viral non-suppression, advanced HIV disease (AHD), and multimorbidity persist, reflecting gaps in service response rathe...

Abstract BackgroundNursing home (NH) residents have a high burden of multimorbidity and disability and are frequently hospitalized. Comprehensive geriatric assessment might reduce hospitalization. However, fe...

IntroductionLate-life difficult-to-treat depression (LL-DTD) and dementia frequently coexist in later life, but it remains unclear whether clinical and sociodemographic characteristics, as well as medication exposure pat...