NODOVOX | Discovery

DNA methylation regulation of CYP450-lipid metabolism by high-altitude hypoxia: linking neuroinflammation to cognitive impairment

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DNA methylation regulation of CYP450-lipid metabolism by high-altitude hypoxia: linking neuroinflammation to cognitive impairment

Qian Wang et al · BMC · 2026 · ISSN 1742-2094

Abstract Under high-altitude hypoxia, neuroinflammation contributes to cognitive impairment, though the underlying mechanisms remain unclear. In this study, we established rat and astrocyte models of hypoxic exposure. We...

LCC LCC:Neurology. Diseases of the nervous systemIdioma eng

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Oral sodium butyrate supplementation acts on intestinal dysbiosis and resolves spinal cord neuroinflammation and nociceptive neuron sensitization

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Oral sodium butyrate supplementation acts on intestinal dysbiosis and resolves spinal cord neuroinflammation and nociceptive neuron sensitization

Antimo Fusco et al · BMC · 2026 · ISSN 1476-9255

Abstract Background Gut microbiota dysbiosis is a key pathological feature closely linked to metabolic disorders and neuroinflammation. It is typically characterized by reduced levels of beneficial microbial metabolites,...

LCC LCC:Therapeutics. PharmacologyIdioma eng

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Bystander activation of microglia by Brucella abortus-infected astrocytes induces neuronal death via IL-6 trans-signaling

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Bystander activation of microglia by Brucella abortus-infected astrocytes induces neuronal death via IL-6 trans-signaling

Rodríguez, Julia et al · Frontiers Media · 2024 · ISSN 1664-3224

Inflammation plays a key role in the pathogenesis of neurobrucellosis where glial cell interactions are at the root of this pathological condition. In this study, we present evidence indicating that soluble factors secre...

Idioma eng

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Neuroinflammation: a critical bridge linking peripheral pathology and age-related degeneration in myasthenia gravis

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Neuroinflammation: a critical bridge linking peripheral pathology and age-related degeneration in myasthenia gravis

Fan-yu Liu et al · Frontiers Media S.A · 2026 · ISSN 2296-858X

Myasthenia gravis (MG) has traditionally been conceptualized as a peripheral autoimmune disorder primarily mediated by autoantibodies targeting the neuromuscular junction. However, this classical paradigm fails to adequa...

LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng

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Low-intensity treadmill exercise preconditioning alleviates post-ischemic stroke injury in mice by inhibiting ischemia-induced inflammation and apoptosis

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Low-intensity treadmill exercise preconditioning alleviates post-ischemic stroke injury in mice by inhibiting ischemia-induced inflammation and apoptosis

Chen Peishan et al · De Gruyter · 2026 · ISSN 2942-6812

The incidence of ischemic stroke continues to rise globally, however, regular physical activity before stroke onset significantly lowers its occurrence. Here, we evaluated whether low-intensity exercise preconditioning c...

LCC LCC:Medicine; TENDOlNwb3J0cw~~Idioma eng

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Culture supernatants from human-derived commensal bacteria alleviate DNCB-induced atopic dermatitis through modulation of inflammatory and barrier-associated pathways

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Culture supernatants from human-derived commensal bacteria alleviate DNCB-induced atopic dermatitis through modulation of inflammatory and barrier-associated pathways

Jaeeun Sin et al · Frontiers Media S.A · 2026 · ISSN 1664-302X

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by immune dysregulation, impaired epidermal barrier function, and recurrent episodes of itching and inflammation. Emerging evidence...

LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng

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Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization

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Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization

Jiacan Xu et al · Frontiers Media S.A · 2026 · ISSN 1663-9812

BackgroundCerebral ischemic injury includes ischemic stroke in adults and hypoxic-ischemic encephalopathy (HIE) in newborns. Delphinidin-3-O-glucoside (Dp3G) is a bioactive anthocyanin abundant in vibrantly colored plant...

LCC LCC:Therapeutics. PharmacologyIdioma eng

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Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies

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Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies

Yesim Kaya et al · Frontiers Media S.A · 2026 · ISSN 1662-5161

Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...

LCC LCC:Neurosciences. Biological psychiatry. NeuropsychiatryIdioma eng

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Endoplasmic reticulum stress inhibitor 4-PBA alleviates immune damage in mice with enteroviral encephalitis by inhibiting ferroptosis

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Endoplasmic reticulum stress inhibitor 4-PBA alleviates immune damage in mice with enteroviral encephalitis by inhibiting ferroptosis

Sijie He et al · BMC · 2026 · ISSN 1743-422X

Abstract Introduction Enterovirus A71 (EV71)–associated encephalitis lacks targeted neuroprotective therapy. Experimental data implicate endoplasmic reticulum (ER) stress and ferroptosis in neuronal injury. We tested w...

LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng

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Increased type 3 deiodinase reduces hippocampal T3 signaling and is associated with cognitive impairment in a sporadic Alzheimer’s disease animal model

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Increased type 3 deiodinase reduces hippocampal T3 signaling and is associated with cognitive impairment in a sporadic Alzheimer’s disease animal model

Rafael Aguiar Marschner et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β and tau pathology, neuroinflammation, oxidative stress, and cognitive decline. Emerging evidence indicates that ...

LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng

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Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity

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Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity

Vinuesa, María Angeles et al · Elsevier · 2016 · ISSN 0306-4530

The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies - constitute major ris...

Idioma eng

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Stress and Brain

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Stress and Brain

Tsinghua University Press; China · ISSN 2709-1325

Materias / palabras clave: stress, neuronal inflammation, brain imaging, psychology, neuroendocrinology, brain behavior; Philosophy. Psychology. Religion: Psychology; Science: Biology (General): Genetics

Idioma English

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