Buscar recursos académicos

La transición del Antiguo Régimen al proceso de revolución e independencia generó en el contexto económico la reorientación definitiva - en el caso del Río de La Plata de los flujos comerciales hacia el Atlántico...

Abstract Objective To investigate whether patients with a previous recombinant follicle stimulating hormone (rFSH)-stimulated cycle would have improved outcomes with rFSH + recombinant luteinizing hormone (rLH) stimula...

This study investigated the individual and synergistic effects of exogenous emulsifiers and lipase supplementation on growth performance, nutrient apparent digestibility, lipid metabolism, and gene expression in broilers...

SASH3 deficiency is an X-linked combined immunodeficiency characterized by recurrent sinopulmonary, cutaneous, and mucosal infections, refractory autoimmune cytopenia, and immune dysregulation. We report here the first t...

Introduction: Polypharmacy carries the potential for increased risk and severity of adverse reactions. Deprescribing may reduce adverse events and possibly hospitalizations, although evidence on hard outcomes such as mor...

Abstract Background Mirogabalin and trimethoprim-sulfamethoxazole (TMP/SMX) are frequently used as supportive purpose during and/or after chemotherapy. Mirogabalin is used to treat neuropathic pain, whereas TMP/SMX is us...

We report a case of a 51-y-old female presenting with synchronous double primary malignancies: advanced endometrial cancer and early-stage lung cancer. One year a post-chemotherapy withdrawal due to toxicity, she develop...

Weiya Zhuang,1 Daozhe Lin,2 Chengliang Chen2 1Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, People’s Republic of China; 2Department of Thyroid an...

Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options following the failure of standard adjuvant therapies. We present a 54-year-old female with stage IV cortisol-secreting ACC that progres...

BackgroundSolid organ transplantation is an effective treatment for end-stage organ diseases, including renal, hepatic, cardiac, and pulmonary failure (1). Long-term graft survival depends on sustained immunosuppression;...

Objective This study aims to evaluate the cost-effectiveness of latent tuberculosis infection (LTBI) screening strategies using interferon-gamma release assays (IGRAs) among migrants, integrating social vulnerability and...

BackgroundRare epidermal growth factor receptor (EGFR) mutations have a low incidence, and their response to EGFR tyrosine kinase inhibitors (TKI) has not been sufficiently studied. L747P is a rare EGFR mutation located ...

Objective To characterise temporal trends in antiretroviral therapy (ART) utilisation and forecast short-term changes in regimen distribution within a provincial HIV treatment programme.Design Population-level longitudin...

DNA ligase IV (LIG4) is essential for repairing breaks in double-stranded DNA via nonhomologous end-joining in developing lymphocytes and is particularly important for V(D)J recombination. First described in the early 20...

Immune checkpoint inhibitors (ICI), particularly antibodies targeting programmed death receptor-1 (PD-1) and its ligand, programmed death-ligand 1, have been rarely associated with the development of immune-mediated diab...

IntroductionTherapies for metastatic renal cell carcinoma (mRCC) have evolved significantly, making treatment decisions more complex. We used machine learning (ML) to identify subgroups of patients who have a high probab...

BackgroundAbdominal primary Ewing sarcoma (ES) is extremely rare and carries a dismal prognosis when metastatic. First-line therapy typically involves multi-agent regimens like VDC/IE, with irinotecan-based combinations ...

OBJECTIVE: Side effects of cisplatin, such as nephrotoxicity, limit its use in chemotherapeutic regimens and indicate an agent that suppresses its toxicity. Thymoquinone (TQ), the predominant bioactive constituent presen...

Abstract Background Platinum-based chemoimmunotherapy is used as a first-line treatment for advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma under specific regulatory circumstances, but effectiveness ...

Abstract Old World orthohantaviruses, including Hantaan virus (HTNV), cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Available inactivated vaccines often induce low neutralizing antibodies and short-term ...

Abstract Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome (HIV/AIDS) is a major public health problem affecting an estimated 38.4 million people globally, with 54% of them being from the Eastern and Sou...

Background: Tuberculosis (TB) remains a global public health challenge, with Thailand identified as a high-burden country for TB and TB-HIV infections by WHO in 2021–2025. While the standard TB treatment regimen—incl...

Introduction. The correlation between psoriasis and metabolic syndrome has been well established. Psoriasis may also coexist with autoimmune blistering disease, mainly bullous pemphigoid. The pathogenetic relationship b...

Mycobacterium wolinskyi (MW) is a rapidly growing mycobacterium that was first identified in 1999 using 16S rRNA gene sequencing. Although the number of reported cases of MW infection has been increasing in recent years,...