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ObjectivePancreatic disorders are characterised by high mortality rates and limited therapeutic options and pose a global health challenge. As a dual-function organ with endocrine and exocrine roles, the pancreas exhibit...

Materias / palabras clave: Enfermedades; Cancér; Pancreas; Diseases; Pancreatitis; Páncreas

The peroxisome proliferator-activated receptors (PPARs), including PPAR-α, PPAR-β/δ, and PPAR-γ, are nuclear receptors that play critical roles in regulating metabolism and inflammation. While PPARs have been extensi...

Abstract Background Pancreatic portal hypertension (PPH) is a distinct form of sinistral (left-sided) portal hypertension, primarily resulting from pancreatic diseases such as acute or chronic pancreatitis and pancreatic...

Abstract Background Awareness of exocrine pancreatic insufficiency (EPI) in cats has increased since the development of an assay for feline trypsin‐like immunoreactivity (fTLI). Ultrasound findings in cats with EPI hav...

Abstract Background While diabetes mellitus (DM) has been reported as a risk factor for development and prognosis of pancreatic ductal adenocarcinoma (PDAC), the specific impact of glycemic control on clinical outcomes r...

Abstract Background and aims Pancreatic duct leaks and fistulas are challenging complications of pancreatitis and pancreatic surgery. Although endoscopic retrograde pancreatic duct drainage (ERPD) is widely used, optimal...

Insulin secretion from pancreatic islet β-cells is governed by both metabolic and electrogenic pathways. The latter involves changes in membrane potential regulated by various potassium channels, including ATP-sensitive...

Immune checkpoint inhibitors (ICPIs)-induced endocrine immune-related adverse events (irAEs) are common, can appear concurrently, and can be overlooked due to their nonspecific presentation overlapping with cancer-relate...

Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...

BackgroundBoth insulin and glucagon have been extensively studied due to their critical roles in glucose metabolism, development, and disease. However, there is limited information about the molecular characteristics of ...

Abstract Background The MARS PETCARE BIOBANK™ (MPB) is a study recruiting pets visiting Mars Veterinary Health hospitals in the USA over a ten-year period, with the aim of analysing longitudinal data from thousands of ...

Diabetes mellitus and cancer are among the most prevalent non-communicable diseases worldwide and increasingly coexist in clinical practice. Epidemiological evidence indicates that type 2 diabetes is associated with elev...

ObjectiveTo determine whether serum exosomal long non-coding RNA AC245100.4 has value for early diagnosis and prognostic stratification in acute pancreatitis (AP), and to examine its potential involvement in inflammation...

Abstract Background Type 1 diabetes (T1D) is a lifelong autoimmune condition characterised by the progressive immune-mediated destruction of insulin-secreting β-cells within the pancreatic islets, culminating in absolut...

We performed a single-center retrospective analysis of chronic granulomatous disease (CGD) autopsy reports to better understand causes of death, end-organ damage, and disease pathophysiology. Forty-four autopsies of CGD ...

BackgroundWestern diet (WD) consumption accelerates the development of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). This study investigated whether chestnut-derived ellagitannins (FT50) modulate early m...

Abstract Objective This study aims to evaluate the clinical features, efficacy of endoscopic therapy, and long-term prognosis in patients with ectopic papilla of Vater (EPV) located in the duodenal bulb. Methods A retros...

Abstract Background Bone marrow-derived cell (BMDC) transplantation is increasingly recognized as a valuable strategy in regenerative therapies. However, the data regarding the impact of BMDC transplantation on the sever...

Abstract A 61‐year‐old man visited our hospital with a sudden onset of polydipsia and polyuria occurring 5 days prior, accompanied by a 5‐kg weight loss. A month prior, his glycated hemoglobin level was 6.2%. Pre...

BackgroundAlthough the association between disorders of immunity and cancer risk is recognized, the prevalence of different malignancies in this population remains incompletely characterized. Large electronic health reco...

We report a rare case of 32-year-old female with malignant reninoma complicated by pulmonary metastasis and ATRX mutation (p.G1964*, VAF 23.73%), initially misdiagnosed as renal pelvic carcinoma and treated with radical ...