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ABSTRACT Background and Aims Human metapneumovirus (hMPV) is a leading cause of acute respiratory tract infections, particularly in children, older adults, and individuals with immunocompromising conditions. Despite incr...

Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultim...

Toxoplasma gondii (T. gondii) is an apicomplexan parasite that infects most warm-blooded animals, including approximately one-third of the human population worldwide. Dense granule proteins (GRAs), secreted from speciali...

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with a high incidence of renal involvement during its course contributing to disease morbidity and mortality. All compartments of the kidney may be affe...

Systemic Lupus Erythematosus (SLE) is a prevalent disease that shows all the characteristics of an autoimmune pathology. The developments in the pathogenic factors in SLE provide new insights to the treatment of SLE and ...

Autosomal-dominant hyper-IgE syndrome (AD-HIES) is characterized by chronic mucocutaneous candidiasis, recurrent sinopulmonary pneumonias, noninflammatory atopic dermatitis, extremely high levels of serum IgE, and non-im...

Purpose. To identify specific risk factors and protective factors to inform tailored screening and management strategies for high-risk individuals. Methods. This case-control study included a total of 800 eyes from 400 i...

Objective Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-depe...

Ingrown toenail is a disease of both children and adults, causing discomfort or pain of varying degrees of severity. Depending on the stage of disease, it is often the cause of significant difficulties in daily life. Eti...

The aim of this review is to describe the main theoretical findings and research conclusions about obsessive-compulsive disorder (OCD) in the perinatal period. On one hand, epidemiological studies show that the risk of O...

BackgroundBehçet’s disease is a multisystem inflammatory disorder whose diagnosis can be challenging due to overlapping features with other inflammatory conditions and primary immunodeficiencies (1). In patients with ...

Reactive oxygen particles can increase tissue injury in the pathogenesis of human diseases. However, some antioxidants are used for therapeutic approach. In this review, the possible roles of reactive oxygen particles ...

Sepsis is a common and important cause of mortality in critically ill patients. Acute kidney injury (AKI) is one of the most important factors determining morbidity and mortality in this clinical picture. Recent studies ...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

Abstract Industrialization and urbanization exacerbate global environmental health challenges, with pollutants from industrial and vehicular emissions (e.g., PAHs, NOx, PM2.5) posing significant risks. Growing evidence l...

To investigate the role and importance of iinmun system on the pathogenesis of uncomplicated RUTIs, 24 children with uncomplicated RUTIs (21 girls, 3 beys; age 5.81.0 years) were studied in the present study. Absolute ...

BackgroundThymoma, a neoplasm of the thymus, leads to hypogammaglobulinemia in ∼10% of affected patients, resulting in Good syndrome that frequently coexists with autoimmunity and mucosal candidiasis. Thymomas lose the...

Zinc is a key micronutrient of the skin, where it is responsible, among others, for regulating the processes of melanocyte proliferation, maturation, and differentiation. Recent research has revealed a possible link betw...

Background: Outer membrane vesicles (OMVs) from Gram-negative bacteria are spherical lipid bilayer nanostructures with diameters of 20 to 250 nm. Porphyromonas gingivalis (P. gingivalis), a keystone periodontal pathogen,...

This literature review aims to synthesize current evidence on plastic bronchitis (PB), a disease characterized by varying degrees of branching cast formation in the airways. The rationale for undertaking this review stem...

Acute renal failure is defined as the abrupt decline in glomeruler filtration rate resulting from ischemic or toxic injury and observed mostly in the critical care units. The most important factors playing role in the ...

The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most ...

The prevalence of co-morbid gastrointestinal symptoms is high in dialysis patients, while abdominal pain, constipation, diarrhea, anorexia and abdominal bloating are the second-most common group of symptoms following dys...

Mansonella ozzardi (Nematoda: Onchocercidae) is an understudied filarial nematode, originally described by Patrick Manson in 1897, that can be transmitted by two families of dipteran vectors, biting midges (most of them ...