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Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultim...

Objective Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-depe...

Ingrown toenail is a disease of both children and adults, causing discomfort or pain of varying degrees of severity. Depending on the stage of disease, it is often the cause of significant difficulties in daily life. Eti...

The aim of this review is to describe the main theoretical findings and research conclusions about obsessive-compulsive disorder (OCD) in the perinatal period. On one hand, epidemiological studies show that the risk of O...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

Abstract Industrialization and urbanization exacerbate global environmental health challenges, with pollutants from industrial and vehicular emissions (e.g., PAHs, NOx, PM2.5) posing significant risks. Growing evidence l...

Zinc is a key micronutrient of the skin, where it is responsible, among others, for regulating the processes of melanocyte proliferation, maturation, and differentiation. Recent research has revealed a possible link betw...

This literature review aims to synthesize current evidence on plastic bronchitis (PB), a disease characterized by varying degrees of branching cast formation in the airways. The rationale for undertaking this review stem...

The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most ...

Mansonella ozzardi (Nematoda: Onchocercidae) is an understudied filarial nematode, originally described by Patrick Manson in 1897, that can be transmitted by two families of dipteran vectors, biting midges (most of them ...

Background/Aim: Cysts which appear in the orofacial region are represented as common pathological changes which underlying mechanism of development is still not fully clear. In recent years, a dominant role in the pathog...

The global evolution of the SARS-CoV-2 virus is known to all. The diagnosis of SARS-CoV-2 pneumonia is expected to worsen, and mortality will be higher when combined with myocardial injury (MI). The combination of novel ...

Previous studies have suggested that macrophages may contribute to acute Leptospira dissemination, as well as having a major role in kidney fibrosis. Our aim was to characterize the role of macrophages and galectin 3 (Ga...

Abstract In recent years, with the continuous booming of diabetes patients, the research on diabetes and its complications, including pathogenesis, early diagnosis and therapeutic interventions, has attracted considerabl...

Background Depression in adolescents is recognised as a global public health concern, but little is known about the trajectory of its clinical symptoms and pathogenesis. Understanding the nature of adolescents with depre...

Abstract Background/Objectives Dilated cardiomyopathy (DCM) is characterized by heart failure and cardiac dilation, distinguishing it from ischemic and non-ischemic heart diseases. To date, more than 50 genes have been i...

Abstract Background Pancreatitis in cats, although commonly diagnosed, still presents many diagnostic and management challenges. Objective To summarize the current literature as it relates to etiology, pathogenesis, diag...

Protein aggregation plays a central role in the pathogenesis of many neurodegenerative diseases and poses major challenges in protein engineering. A key driver of this process is the presence of aggregation-prone regions...

Background: Emerging evidence has shown that exposure to polycyclic aromatic hydrocarbons (PAHs) is a risk factor for rheumatoid arthritis (RA). Benzo[a]pyrene (BaP), a representative PAH congener, exacerbates the develo...

Anti-glutamic acid decarboxylase (anti-GAD) autoimmunity possess a poorly understood diversity in the development of neurological manifestations with or without diabetes mellitus (DM) association. A possible genetic cont...

O parto prematuro é a principal causa de morbidade e mortalidade neonatal. Cerca de 75% dos nascimentos prematuros são decorrentes do trabalho de parto espontâneo. A patogenia do parto prematuro espontâneo é complex...

Tripartite motif (TRIM)7 is an E3 ubiquitin ligase that was first identified through its interaction with glycogenin-1 (GN1), the autoglucosyltransferase that initiates glycogen biosynthesis. A growing body of evidence i...

Background: Copper (Cu) is an essential trace metal used as a catalytic cofactor for many enzymes. However, it can have nocive effects when it participates in the Fenton reaction, producing reactive oxygen species (ROS)....

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...