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Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of complications with rising complexity, particularly as EBV-negative forms are increasingly recognized in adult recipients. While earl...

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by aberrant immune responses and tissue remodeling. Ligustrazine has multiple effects, such as enh...

ObjectiveTo investigate the predictive value of serum citrullinated histone H3 (CitH3) and thymic stromal lymphopoietin (TSLP) for postoperative wound healing outcomes in patients with pilonidal sinus (PS), and to constr...

PurposeThis study aimed to investigate the associations between gut metabolites Trimethylamine N-Oxide (TMAO), the novel platelet-derived inflammatory ratio index neutrophil-to-platelet ratio (NPR), and the prognosis of ...

Abstract Immune checkpoint inhibitors (ICI) have transformed the treatment of metastatic malignancies, yet only 20–40% of unselected patients benefit. Peripheral blood could offer a minimally invasive and dynamic sourc...

Abstract Background The recurrence of small intestinal hemorrhage (SIH) poses a significant clinical challenge owing to the absence of reliable and accessible predictive biomarkers. This study aimed to identify a crucial...

ObjectiveThis study aimed to analyze the factors associated with infection after kidney transplantation and to explore the predictive value of Th17/Treg cells and cytokine levels for infection.MethodsA retrospective anal...

Weiming Hao,1 Ruigao Song,1 Huimin Lv,1 Chunying Song2 1Reproductive Medicine Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiy...

Abstract Backgrounds Acute primary angle-closure glaucoma (APACG) and chronic primary angle-closure glaucoma (CPACG) exhibit distinct clinical features, yet the molecular mechanisms underlying their differing progression...

ObjectiveThis study aimed to identify core inflammatory biomarkers through machine learning approaches and develop an accessible online risk calculator to predict pulmonary consolidation in children with Chlamydia pneumo...

Background: Exposure to individual neonicotinoids (NNIs) suggestively correlates with the type 2 diabetes mellitus (T2DM) risk in animals. However, existing systematic epidemiological investigations remain scarce and lac...

IntroductionAnti-amyloid antibodies have the potential to become the standard of care in Alzheimer’s Disease (AD) and large datasets from clinical trials allow the testing of predictive models on fluid biomarkers and f...

Immune checkpoint inhibitors (ICIs) have been game changer in cancer therapy but can trigger diverse immune-related adverse events (irAEs) that impact multiple organs. This review offers a unified perspective on irAE ris...

Background Individual differences have been detected in individuals with opioid use disorders (OUD) in rehabilitation following protracted abstinence. Recent studies suggested that prediction models were effective for in...

ABSTRACT Background and Aims The imbalance of oxidants and antioxidants mediates cell damage through a phenomenon known as oxidative stress. The increase in fertility problems led to a growing focus on factors that affec...

Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability worldwide. Endovascular mechanical thrombectomy (EVT) has revolutionized stroke treatment by enabling rapid recanalization of occl...

Abstract Objectives IgG4-related disease (IgG4-RD) is an immune-mediated condition with diagnostic challenges in clinical practice. Sensitive biomarkers are needed for diagnosis, disease activity and disease progression ...

Abstract Background Treatment is indicated in dogs with preclinical degenerative mitral valve disease (DMVD) and cardiomegaly (stage B2). This is best diagnosed using echocardiography; however, relying upon this limits a...

Isac Wickman,1 Ivana Huzevkova,1 Marion Schroeder,1 Elisabet Granstam,2 Ulrika Kjellström,1 Monica Lövestam-Adrian1 1Department of Clinical Sciences Lund, Ophthalmology, Lund University, Lund, Sweden; 2Department of Su...

Jiayin Chen,* Zhuochao Li,* Xun Qi Key Laboratory of DiagnosticImaging and Interventional Radiology of Liaoning Province, Department of Interventional Therapy, The First Hospital of China Medical Universi...

Abstract The introduction of biologicals interfering with the interleukin-5 (IL-5) pathway has revolutionized the treatment of severe eosinophilic asthma (SEA), rendering remission an achievable goal even in patients wit...

ObjectiveTo provide data support for infectious mechanism and microecological intervention strategies， the structural and functional alterations of the gut microbiota in patients with norovirus associated diarrhea was ...

Preeclampsia represents an unmasking of underlying vascular and metabolic vulnerability during the physiologic stress of pregnancy. Current first-trimester screening relies heavily on body mass index which incompletely c...