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Yu Luo,1 Suning Huang,1,2 Haichuan Xie,3 Bei Zhang,3 Fei Ma,1– 4 Yanting Lin,1– 4 Yan Ning,1– 4 Jiaman Wu1– 4 1Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People’s R...

Abstract Multifocal Ectopic Purkinje-related Premature Contractions (MEPPC) syndrome is a recently recognized rare channelopathy caused by gain-of-function mutations in the SCN5A gene, leading to a high burden of prematu...

ABSTRACT Background and Aims Preterm neonates are at higher risk of cumulative procedural pain at a crucial point in brain development. Several procedures performed in neonatal intensive care units (NICUs) have ineffecti...

BackgroundCaffeine is one of the most frequently administered medicines in neonatology—prescribed for the management of apnoea of prematurity, to aid extubation and increasingly for conditions such as bronchopulmonary ...

Abstract Recent studies have demonstrated that exosome therapy can promote the recovery of ovaries in premature ovarian failure (POF) models, which may aid in fertility restoration. This study aimed to investigate the th...

ObjectiveNecrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality in preterm infants; however, early diagnosis is limited by the lack of reliable circulating biomarkers. This study aimed to eval...

Deficiency in ELF4, X-linked (DEX) is a monogenic autoinflammatory disorder caused by loss-of-function (LOF) mutations in the ETS transcription factor ELF4. This rare disorder primarily affects young, male patients due t...

ABSTRACT In this paper, we develop a photothermal‐responsive hydrogel (CNB‐ePRP) based on engineered platelet‐rich plasma (PRP)/sodium alginate (SA) hydrogel integrating thrombin‐functionalized composite nanobott...

Abstract Background Non-communicable diseases (NCDs) are the leading cause of premature death in Europe and disproportionately affect persons experiencing disadvantages (i.e., low-income populations, migrants and ethnic ...

Abstract Background Myosin heavy chain (MyHC)-related congenital myopathies display variable age of onset and clinical manifestations depending on the mutated isoform. Cardiomyopathy, ophthalmoplegia and primarily proxim...

Abstract Carbon dioxide enhanced oil recovery (CO2-EOR) offers dual benefits of increasing hydrocarbon production and sequestering anthropogenic CO2; however, conventional CO2 flooding suffers from unfavorable mobility r...

Abstract Background Adverse events across the lifespan have been linked to poorer health outcomes, but the biological mechanisms remain unclear. The aim of this study was to quantify the independent and joint association...

ABSTRACT Background Adolescents with type 1 diabetes (T1D) face premature atherosclerosis, but standard carotid intima‐media thickness (IMT) may lack sensitivity for the earliest vascular injuries. Since urinary albumi...

The genetic algorithm (GA) is a widely recognized optimization technique for addressing complex and NP-hard problems; however, its effectiveness is often hampered by issues such as premature convergence and population di...

Abstract Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. Here, to investigate strategies that alleviate mitochondrial dysfunction, we first generate ...

Abstract Background Iodine plays a critical role in producing thyroid hormones essential for brain development. An imbalance of iodine, whether deficiency or excess, can disrupt thyroid function. Iodine-induced hypothyro...

Introduction: Pneumothorax in premature neonates remains a significant clinical issue, especially when linked to respiratory distress syndrome and systemic inflammation. Providing early respiratory support and customized...

BackgroundHMPV is a leading cause of pediatric lower respiratory tract infections, second only to respiratory syncytial virus in causing severe pneumonia in children. Its clinical presentation closely mimics other common...

Abstract Background Vertical transmission is the main mode of acquisition of HIV infection in the Democratic Republic of Congo (DRC). We aimed to determine the factors associated with the serological status of mothers an...

Abstract Background Progressive retinal atrophy (PRA) was diagnosed in four related male English Cocker Spaniels (ECS) between the ages of 3 and 4 years. All affected dogs were born to clinically unaffected parents that ...

Abstract Working with co-occurring mental health and substance use problems has been identified as particularly difficult and demanding for clinicians. This contributes to occupational stress, which can lead to increased...

Abstract Re-entrant auxetic lattices exhibiting negative Poisson’s ratio behaviour are attractive for lightweight energy-absorbing applications. However, traditional re-entrant and hexagonal auxetic designs often exhib...

Concrete-filled steel tubular (CFST) truss arch bridges are widely used in long-span bridge construction due to their high strength, good stiffness, and excellent durability. However, arch rib joints, as critical load-be...

Abstract Land subsidence induced by underground coal mining consistently leads to persistent ponding in coal-grain overlapping areas (COAs), substantially impairing agricultural productivity. However, amid stringent farm...