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Aims: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3...

Abstract Background Copper (Cu), zinc (Zn), and the copper/zinc ratio (Cu/Zn), which have been studied in gastrointestinal disorders of humans, may facilitate disease prognosis. Objective Evaluate the predictive potentia...

IntroductionSkin cancer, including basal cell carcinoma, squamous cell carcinoma, and melanoma, is one of the most common cancers worldwide. Matrix metalloproteinases are zinc-dependent proteolytic enzymes that play a cr...

BackgroundThe Naples prognostic score (NPS), derived from routine inflammatory and nutritional biomarkers, reflects systemic immune–metabolic status. Its prospective association with Parkinson disease (PD) risk has not...

Abstract Background Differentiating benign from canine malignant mammary tumors requires invasive surgical biopsy. Circulating microRNAs (miRNA) may represent promising minimally invasive cancer biomarkers in people and ...

Mehmet Zafer Aydın,1 Can Baba Arin,2 Mehmet Kamil Teber,1 Zülfiye Kuzu,1 Mustafa Gök,1 Ishak Ahmed Abdi3 1Department of Cardiology, Kayseri City Training and Research Hospital, Kayseri, Turkey; 2Department o...

Abstract Immune checkpoint inhibitors (ICI) have transformed the treatment of metastatic malignancies, yet only 20–40% of unselected patients benefit. Peripheral blood could offer a minimally invasive and dynamic sourc...

Abstract Background Systemic inflammation and nutritional status are increasingly recognized as prognostic determinants in glioblastoma (GBM). The CRP–albumin–lymphocyte (CALLY) index integrates inflammatory and immu...

Abstract Background The optimal heart rate (HR) in dogs with atrial fibrillation (AF) is unknown. Impact of HR on survival needs elucidation. Hypothesis/Objectives Dogs with a 24 hours Holter‐derived meanHR ≤125 be...

BackgroundAcute respiratory distress syndrome (ARDS) secondary to severe acute pancreatitis (SAP) is associated with high mortality; however, dependable biomarkers for early risk assessment remain scarce. The lactate-to-...

Abstract Background Immune checkpoint inhibitors (ICIs) have become the main treatment method for human epidermal growth factor receptor 2 (HER2)-negative advanced gastric cancer (GC). This study analyzed from real-world...

Abstract Insulin resistance (IR) has emerged as a metabolically relevant contributor to the development and progression of breast cancer (BC), with a case fatality of nearly 15%. IR mainly shows a relationship with obesi...

Objective: To explore the imaging biomarkers obtained from baseline multi-modality imaging PET/CT before metastasis-directed therapy (MDT), which could offer early response prediction before MDT treatment, optimizing pat...

Abstract Objective Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with rising incidence globally. Current prognostic markers often lack precision for individualized management. This study develo...

Resumen: Introducción: La incidencia de cáncer de mama (CM) en mujeres jóvenes ha aumentado, pero existen pocos estudios que analicen factores pronósticos en este grupo etario. Métodos: Estudio retrospectivo de pac...

BackgroundImmune checkpoint inhibitors (ICIs) have transformed treatment of locally advanced gastric cancer (LAGC), yet response heterogeneity and immune-related adverse events (irAEs) remain major challenges. Systemic i...

ABSTRACT Background and Aims In‐hospital death and recovery are competing risks in COVID‐19 patients, complicating prognosis. While international prognostic scores exist, their reliance on complex biomarkers limits t...

Preeclampsia (PE) complicates 2 % to 8 % of pregnancies and remains the leading cause of perinatal maternal and neonatal mortality worldwide. Early identification of high-risk pregnancies allows for the reduction of comp...

Head and neck squamous cell carcinoma (HNSCC) is characterized by frequent recurrence and poor survival, highlighting the need for reliable biomarkers for risk stratification and therapeutic guidance. Folate-mediated one...

Tiancheng Lu,1 Boren Zheng,1 Dongyao Wang,1 Weihao Liao,1 Chang Su,2 Xiaoyu Wu,2 Xiaojun Zhong,3 Xinle Chen,3 Guozheng Ying,3 Yong Cai,4 Quan Du,5 Xiaoqiao Dong5 1The Fourth School of Clinical Medicine, Zhejiang Chinese ...

Abstract Background NEDD8 ultimate buster 1 is an interferon-inducible tumor suppressor increasingly recognized as a prognostic biomarker in breast cancer. Low cytoplasmic expression correlates with aggressive disease, y...

Key Points. Elevated fractional excretion of potassium (FEK) at biopsy predicts a lower rate of proteinuria remission in adults with nephrotic syndrome. FEK levels vary by histologic types, being low in minimal change di...

Abstract Bacteriophages constitute a major component of the human gut virome, playing very important roles in shaping of the structure and function of the gut microbiota. Moreover, bacteriophages interact with the human ...