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Abstract The systematic exploration of novel bioactive compounds with superior functional properties is critical for driving innovations in agriculture, healthcare, and related fields, thereby becoming essential for adva...

Abstract Background As the most important plant-based protein ingredient in animal husbandry, soybean meal has become key focu in the feed industrym highlighting the need to reduce its inclusion rate and identify alterna...

Abstract Mycosporine‐like amino acids (MAAs) are natural sunscreens synthesized by a wide range of organisms. Although the induction of MAA production by ultraviolet radiation is well established, the signaling pathway...

IntroductionSiderophores are secondary metabolites with high affinity and specificity for iron and play a crucial role in iron acquisition. Vibrio fluvialis, an emerging foodborne opportunistic pathogen of increasing con...

Abstract Background Vascular calcification is a major pathological process driving cardiovascular morbidity and mortality, yet effective therapies are lacking. This study aims to identify novel causal plasma proteins and...

Abstract Background Tenacious glume a key trait limiting threshing efficiency in synthetic hexaploid wheat (SHW), represents an ancestral defense mechanism inherited from wild progenitors. Despite its evolutionary import...

Abstract Background Enhancing nitrogen use efficiency (NUE) is essential for sustainable agriculture. Stress response pathways play a significant role in regulating NUE across various growth stages and organs. Therefore,...

Ganoderic acids (GAs), the major lanostane-type triterpenoids in Ganoderma lucidum (G. lucidum), possess diverse pharmacological activities but are produced at low levels, limiting their applications. Transcriptional reg...

IntroductionPancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and invasive malignancies, with limited response to the currently available systemic therapy options. Having a 5-year survival of 12%...

Abstract Background Ophiocordyceps sinensis is a premier medicinal fungus with a unique slow-killing parasitic strategy, yet the molecular basis of its long-term persistence in host hemocoel remains elusive. This fungus ...

Abstract The activating signal co-integrator 1 complex subunit 3 (ASCC3), a multifunctional protein, has been implicated as a prognostic marker in several types of cancer. However, mechanisms underlying its prognostic va...

"The diverse repertoire of cell surface glycans, generated by the coordinated activity of glycosyltransferases and glycosidases, encodes critical biological information that is interpreted by glycan-binding proteins incl...

Abstract Background Flowering time is a key phenological trait in chickpea (Cicer arietinum L.), determining adaptation to different agro-climatic conditions and directly influencing yield. Here, we investigated the gene...

Abstract Psammochloa villosa is a perennial herbaceous plant belonging to tribe Stipeae (Poaceae). It is mainly distributed in the arid and sandy Inner Mongolia Plateau and adjacent areas, demonstrating remarkable resili...

Abstract Background The conidia of filamentous fungi play a crucial role in the development and dissemination, which is precisely regulated by multiple genes and controlled by a central regulatory network. The novel tran...

Smilax glabra, a perennial vine with high pharmaceutical value, exhibits seed dormancy under natural conditions that severely restricts artificial propagation and industrial-scale cultivation. This study aims to systemat...

Abstract Fungal inositol phosphorylceramide (IPC) synthase is an essential enzyme complex that catalyzes a critical step in sphingolipid biosynthesis. It is the molecular target of potent antifungal aureobasidin A (AbA)....

BackgroundEndometriosis is a complex gynaecological disorder that affects 10%–15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction...

Coenzyme A (CoA) is a vital cofactor involved in energy metabolism, lipid biosynthesis, protein modification, and epigenetic regulation. Disruptions in CoA biosynthesis have been implicated in neurometabolic disorders su...

Abstract Selenium (Se) enriched forest-grown ginseng is famous for its high Se content and excellent protein quality, which are necessary for varieties of metabolic processes and play an important role in both ginseng gr...

Platelets play a crucial role in atherothrombosis, as demonstrated by the effectiveness of the antiplatelet agent aspirin (acetylsalicylic acid, ASA) in the secondary prevention of cardiovascular disease. Low-dose aspiri...