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BackgroundTraumatic brain injury (TBI) with post-traumatic stress disorder (PTSD) is treatment-resistant, with conventional psychotherapy showing limited efficacy due to neurocognitive impairments.Case SummaryWe report t...

Christos Kleisiaris,1 Theodora Arida,2 Maria Klesiora,1 Konstantinos Tsaras,1 Maria Malliarou,1 Ioanna V Papathanasiou,1 Theodosios Paralikas,1 Nikolaos Bakalis,3 Mahmoud Ogla Al-Hussami,4 Wafa Hamad Almegewly,5 Savvato ...

Chronic psychosocial stress is a major risk factor for anxiety, depression and related disorders, yet a hypothalamic-pituitary-adrenal (HPA) axis centric framework alone is insufficient to explain stress-induced vulnerab...

Tinghan Fu,1– 3,* QianQian Wang,1– 3,* Shasha Chen,1– 3,* Tiannan Xu,1– 3 Hongye Wu,1– 3 Ruimei Ni,1– 3 Kai Zhang2– 4 1School of Mental Health and Psychological Science, Anhui Medica...

Abstract Background Generative artificial intelligence (AI) chatbots are being increasingly adopted by adolescents to address mental health–related concerns, such as seeking emotional reassurance, clarifying symptoms, ...

Abstract Thalamocortical circuits regulate information flow between sensory inputs and higher-order processing, and their disruption is increasingly implicated in psychotic disorders. However, scalable biomarkers of this...

BackgroundAttention deficit/hyperactivity disorder (ADHD) is characterized as a neurodevelopmental disorder onset in childhood. However, accumulating evidence suggests that some adults may fulfill current diagnostic crit...

BackgroundDepressive disorders are clinically heterogeneous and mechanistically complex psychiatric conditions. Transcranial direct current stimulation (tDCS), a key non-invasive neuromodulation technique, has expanded r...

Introduction Paediatric anxiety disorders are among the most common psychiatric disorders of childhood and adolescence, affecting between 15% and 30% of youth. Rates rose sharply during the COVID-19 pandemic, and untreat...

INTRODUCTION: This study aimed to investigate serum levels of proline, prolidase, proline dehydrogenase (PRODH), and reactive oxygen species (ROS) in patients with schizophrenia and healthy controls, to evaluate potentia...

Abstract Melatonin plays a key role in circadian regulation, and its interaction with the gut microbiota may be critical for early-life development. Beyond its circadian function, melatonin dysregulation is implicated in...

Abstract Background Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that...

Introduction: Olfactory Reference Syndrome (ORS) is a rare, under-recognized, and understudied psychiatric condition characterized by a persistent belief about the perceived odor, ideas of reference, and engagement in re...

Ahmad H Almadani,1,2 Ayedh H Alghamdi,1,2 Falwah S Alsalman,3 Abdullah J Alghanim,4 Refan T Hashim,2 Abdulrahman I Binbakhit,5 Aleen A Alkulyah,5 Reema M Almutairi,5 Laila A Alfarhan,5 Abdullah K Muhnna,5 Malak M Aldakhi...