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Background and objectivesMitochondrial dysfunction and oxidative stress are key contributors to the progression of Alzheimer’s disease (AD). Salidroside, a bioactive glycoside derived from Rhodiola rosea, exhibits neur...

The fascia, a pervasive connective tissue network, has traditionally been studied for its structural and biomechanical roles in the human body. However, emerging evidence suggests that fascia may also play a significant ...

BackgroundThis study investigated whether manual therapy applied to tendon organs ameliorated neuromuscular dysfunction in rats with spasticity induced by upper motor neuron injury associated with spastic cerebral palsy,...

Background and purposeRadiotherapy (RT) often causes delayed radiation-induced brain injury (RBI) with unclear pathophysiology; emerging evidence links this to glymphatic dysfunction, but radiation effects on cerebrospin...

Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is an efficacious therapy for treatment-resistant depression (TRD) and is thought to drive neuroplastic changes in affective networks. However, up t...

Background: Chronic low-grade systemic inflammation is implicated in the pathophysiology of schizophrenia, particularly in its early stages. Pro-inflammatory and anti-inflammatory cytokines have been implicated, particu...

Abstract Objective To assess frontal lobe dysfunction in incarcerated juvenile delinquents. Methods: A cross-sectional study was carried out in two correction institutions in Cairo where 50 admitted juvenile delinquents ...

Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...

Abstract Introduction Sexual dysfunction is common in patients with psychotic illness. This article describes the translation and cross-cultural adaptation of the Sexual Function Questionnaire (SFQ) into Brazilian Portu...

IntroductionAssessing attention and frontal lobe function is essential for diagnosing dementia. The Stroop test is widely used for these purposes, and its validity and reliability have been verified. Nevertheless, test-r...

IntroductionIn adults, Metacognitive therapy (MCT) for Generalized anxiety disorder (GAD) has demonstrated to be an effective treatment, and even superior to comparisons in randomized controlled trials. One explanation f...

IntroductionVisual electrophysiology, including electroretinograms (ERG) and visual evoked potentials (VEP), provides a real-time functional assessment of retinal and post-retinal pathways, complementing structural imagi...

Abstract Objective Impairments involving inhibitory control have been considered central deficits in drug users, but it appears that dysfunctions may be specific to users’ drug of choice. This article aims to review ...

Yueling Wang,1,* Juntao Yang,2,* Ying Ye,1 Lihua Lu,1 Haolei Wang,1 Peipei Guo,1 Na Hou,1 Xiaohan Huang,3 Cairui Li4 1Department of Medical Imaging, Mental Hospital of Yunnan Province, Kunming, 650000, Pe...

Abstract Introduction: According to the literature, children's overall reactivity to stress is associated with their socioeconomic status and family environment. In turn, it has been shown that reactivity to stress is ...

IntroductionAlzheimer’s disease (AD) is strongly associated with cerebrovascular dysfunction and impaired glymphatic clearance. These dysfunctions may precede, contribute to, and interact bidirectionally with AD pathol...

Background The importance of psychosocial functioning in the assessment, diagnosis and treatment of major depressive disorder (MDD) is widely recognised. However, there is a lack of effective scales to assess psychosocia...

Kai Chen,1,* Yiqing Nong,1,* Ying Liu,2 Ziming Ye3 1Department of Neurology, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, 530023, People’s Republic of China; 2Department of Rehabilitat...

BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons, which results in motor issues such as tremors, stiffness, and slowness of movement. In additio...

IntroductionMachiavellianism was repeatedly found to be associated with personality dysfunction. The Alternative Model for Personality Disorders offers a dimensional approach to personality disorders including level of p...

Poststroke anxiety and depression (PSAD/PSAnx) are common and heterogeneous emotional disorders among stroke survivors, significantly impacting functional recovery, quality of life, and long term prognosis. Their pathoge...

Background Non-suicidal self-injury (NSSI) is a frequent and prominent phenomenon in major depressive disorder (MDD). Even though its prevalence and risk factors are relatively well understood, the potential mechanisms o...

Abstract Eating disorders (ED) are a group of potentially severe mental disorders characterized by abnormal energy balance, cognitive dysfunction, and emotional distress. Cognitive inflexibility is a major challenge to s...

Abstract Background Takotsubo syndrome (broken-heart syndrome) is considered a cardiac disorder typically associated with exposure to severe psychological or physical stress, and it clinically resembles acute coronary sy...