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Abstract Objective The study aimed to evaluate the hypoxia-induced brain injury and neuroprotective effects of pyrimidine and its derivative, arylvinylpyrimidine (AVP), in the freshwater catfish, Heteropneustes fossilis....

In this paper the compounds (11-20) (methyl pyrimidine - 2(1H)-one and others phenyl pyrimidine -2(1H)- one) that will prepared from α, β unsaturated carbonyl compounds they are called chalcones, that compounds prepare...

ABSTRACT Substituted amidines (1,2) where prepared from the condensation of benzyl, furfuryl alcohols and ethyl sulphate with thiourea. Chalcone compounds (3,5a and 5b) where also prepared from condensation of 4-nitroben...

Abstract The research article reports a simple strategy through Vilsmeier Haack formylation for the synthesis of ethyl 1-formyl-1,2,3,6-tetrahydro-4-methyl-2-oxo/thioxo-6-phenylpyrimidine-5-carboxylates. The most facile ...

Recently, DNA molecules have received great attention because of their potential applications in material science. One interesting example is the production of highly fluorescent and tunable DNA–Agn clusters with cytos...

We report here the virtual screening design, synthesis and activity of eight new inhibitors of SphK1. For this study we used a pre-trained Graph Convolutional Network (GCN) combined with docking calculations. This explor...

This study include the synthesis of the compound 1-(1H-benzo[d]imidazol-2-yl)ethanol [1], from the reaction of ortho pheneylene diamine with lactic acid and then oxidized using potassium dichromate to give1-(1H-benzo[d]i...

ABSTRACT In this paper the Synthesis of some substituted 2-Chloro-3-formyl quinoline (2a–d) by treating various substituted acetanilide or 1-(4-substituted phenyl) ethanone oxime with POCl3 in dimethyl formamide. It pr...

A toxicidade aguda e as atividades anti-edematogênica e anti-nociceptiva da 3,4-diidro-2-fenil- 6-para-flúor-fenil-4-oxo-pirimidina-5-carbonitrila (PFP) foram avaliadas em roedores. A DL50 da PFP, determinada por via i...