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ABSTRACT Background and Aims While Masson's Trichrome is widely used for collagen visualization, its qualitative nature limits reproducibility and statistical comparison. A methodological gap persists in the quantitative...

Abstract Introduction Quantitative bias analysis (QBA) methods have been developed, with growing applications to epidemiological studies. Bayesian QBA (BQBA) methods may be superior in effectively using evidence-based pr...

ABSTRACT Background and Aims Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and neurodegeneration. Conventional MRI techniques lack specificity for ...

Critical thinking skills contribute to the development of problem-solving skills. Therefore, when students use problem-solving skills, they are also using their critical thinking skills. This study aims to analyze the re...

Abstract Background Our research team has used the highly cited Consolidated Framework for Implementation Research (CFIR) a priori throughout the research process to better understand influences on implementation outcome...

# Background The countermovement jump (CMJ) is commonly used to assess neuromuscular performance in athletic populations; however, force plate–derived mechanical metrics may not fully reflect central nervous system (CN...

IntroductionProgressive lung disease remains the leading cause of morbidity and mortality in patients with STAT3 hyper-IgE syndrome (HIES), despite optimal supportive care. Forced expiratory volume in 1 second (FEV1) is ...

ABSTRACT: Objective: To investigate the effects of commonly prescribed antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs) during early life on enamel development through a systematic review with quantitative ...

Abstract Glaucoma trabecular meshwork (GTM) cells cultured in vitro retain many characteristics of their in situ phenotype. Here, we used isobaric tandem mass tags (TMTpro) to label peptides from glaucomatous and non-gla...

IntroductionQuantitative choroidal blood flow assessment is important for understanding chorioretinal diseases. Laser Doppler Holography (LDH) is a new non-invasive imaging technique that provides full-field, high-tempor...

Abstract Background Programmed death-ligand 1 (PD-L1) is widely used as a predictive biomarker for response to immune checkpoint inhibitors in gastric cancer (GC); however, its independent prognostic value for overall su...

IntroductionAnti-amyloid antibodies have the potential to become the standard of care in Alzheimer’s Disease (AD) and large datasets from clinical trials allow the testing of predictive models on fluid biomarkers and f...

IntroductionHead and neck cancer (HNC) is a major global health issue, often linked to smoking, alcohol, and viruses (HPV, EBV). HPV-driven oropharyngeal squamous cell carcinoma (OPSCC) showed distinct biology and better...

Abstract Background Children with Unilateral Cerebral Palsy (UCP) are characterized by significant upper limbs (ULs) impairment that hinders daily activities and participation, requiring accurate assessment. Although mot...

BackgroundDiffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma, exhibits genetic heterogeneity and variable treatment responses. Discovering new therapeutic targets is critical to improve outcomes....

Abstract Background Most climate and health studies are based on a single extreme weather event and do not consider multiple physical processes across spatial and temporal scales. Our aim was to explore the current lands...

Abstract Art-historical research has traditionally emphasized qualitative interpretation and visual analysis, but recent advances in machine learning have enabled the quantitative examination of visual and stylistic feat...

Abstract Background The holistic health of children, encompassing physical, psychological, and social domains, plays a crucial role in long-term societal development. However, evidence suggests that many young people eng...

ABSTRACT Background Despite the emphasised benefits of exclusive breastfeeding (EBF) among pregnant and breastfeeding mothers being recognised globally, its practice is still low among developing countries, including Tan...

OBJECTIVES: Concerns about the health and well-being effects of high after-hours availability expectations and work-related connectivity have prompted calls for organizational and national disconnection measures, such as...

Topicality of comparative study in Foreign Direct Investments (FDI) is determined by the need to deepen analysis of economic activity challenges and opportunities related to cross-border investments. Research in FDI tren...

BackgroundChronic wounds remain a significant challenge in healthcare due to persistent inflammation and disrupted macrophage polarization.ObjectiveIn this study, we conducted a quantitative comparative analysis to asses...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with strong invasiveness, limited treatment options, and poor prognosis. Its early accurate diagnosis and individualized treatment are major challenges f...