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Abstract Background Anti-amyloid monoclonal antibodies are entering clinical practice for early symptomatic Alzheimer’s disease (AD), but European real-world data on feasibility, safety, and biomarker monitoring remain...

IntroductionAssisted reproductive technology (ART) practice varies widely across centers and evolves rapidly, often outpacing the generation of randomized evidence. OPERA (Observational ProjEct for a Research database fo...

Basic research involving animal models is an important tool to improve our understanding of clinical conditions related with anxiety and panic attacks. In fact, animal models have been used to study several paradigms on ...

IntroductionClinical simulation has become established as a key tool in healthcare education; however, evidence regarding its multidisciplinary implementation in university hospitals, integrating distinct professional pr...

Nantawan Tippayanate,1,2 Kiattisak Chaiprom,1 Waranya Chatuphonprasert,3 Ajchara Khamya,1 Jantana Sriprow,1 Chattarin Sripol,1,2 Maitree Thronsao1,2 1Field of Study in Paramedicine, Faculty of Medicine, Mahasarakham Univ...

IntroductionVisual electrophysiology, including electroretinograms (ERG) and visual evoked potentials (VEP), provides a real-time functional assessment of retinal and post-retinal pathways, complementing structural imagi...

To address the objective in a clinical trial to estimate the mean or mean difference of an expensive endpoint Y, one approach employs a two-phase sampling design, wherein inexpensive auxiliary variables W predictive of Y...

Abstract Background Adaptive designs (ADs) are increasingly used, whereby outcome data accumulated during the trial may inform a trial’s course in accordance with pre-specified rules at interim analyses. The benefits h...

Emily Kutrieb,1 Derek Weycker,1 Montserrat Vera-Llonch,2 Arthur Zbrozek,3 Kevin Ottino,1 William R Lumry4 1Avalere Health, Washington, DC, USA; 2Ionis Pharmaceuticals, Boston, MA, USA; 3Ionis Pharmaceuticals, Carlsbad, C...

Abstract Background The European Reference Network for rare Inherited and Congenital Anomalies (ERNICA) aims to improve care for patients with rare and complex digestive and gastrointestinal diseases across Europe throug...

Effective medical communication is essential for safe, patient-centred, and collaborative allied health practice, highlighting the need for English courses that address discipline-specific communication demands. This stu...

Abstract Background As the global incidence of pediatric Inflammatory Bowel Disease (IBD) rises, so does the complexity of its psychosocial burden. While biomedical protocols for clinical management are robust, the subje...

Abstract Background Adequate bowel preparation is critical for the success of pediatric colonoscopy. International guidelines recommend standardized low-volume regimens, although several studies also support individualiz...

Fast and accurate identification of skin lesions is important for the outcome of patients. The evaluation of lesions is subjective, and poor quality images may limit accuracy. Deep learning models can be an alternative; ...

Abstract The combination of optical fiber and phototheranostic agents has emerged as a promising strategy to address the challenges of limited light penetration depth and systemic toxicity of nanomaterials. However, the ...

Abstract Language plays a central role in the assessment of individuals with psychosis, from taking a medical history to evaluating cognitive function. However, speaking multiple languages can significantly influence lin...

Saliva as a microfluidic system offers numerous advantages for both general and oral health diagnostic and therapeutic procedures since its assembly is quick, stress-free, inexpensive and non-invasive. Moreover, saliva i...

Abstract BackgroundReal-time force feedback is essential in many surgical specialties. While previous research has focused on force measured at the tool-tissue interface, little work has explored the benefits...

Abstract Background Spontaneous intracranial hypotension (SIH) is an underrecognized condition with rapidly evolving diagnostic and therapeutic strategies. This study investigated temporal and regional trends in diagnost...

The research investigates how cyber science education combines with healthcare technology during the digital age to resolve a fundamental research gap in these two advancing areas. A combined approach utilizing extensive...

La valoracion del estado de salud declarado se puede hacer de manera general o de forma especifica. Una estimacion general de estado de salud se tiene a traves de una respuesta general ante una pregunta del tipo: ?como e...

BACKGROUND: In systematic reviews and meta-analysis, researchers often pool the results of the sample mean and standard deviation from a set of similar clinical trials. A number of the trials, however, reported the study...

Materias / palabras clave: real-world studies, real clinical practice research, non-interventional studies, real clinical practice, real-world evidence, real-world data; Medicine: Medicine (General)