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74 resultados encontrados.

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Real-world evidence of lower-dose intensity of immune checkpoint inhibitors in MSI-H/dMMR gastrointestinal cancers from a resource-constrained setting
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Real-world evidence of lower-dose intensity of immune checkpoint inhibitors in MSI-H/dMMR gastrointestinal cancers from a resource-constrained setting
Mohamad Mourad et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundImmune checkpoint inhibitors (ICIs) have markedly improved outcomes in metastatic microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR) gastrointestinal (GI) malignancies. However, in frag...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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A systematic literature review of real-world evidence (RWE) on post-market assessment of medical devices
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A systematic literature review of real-world evidence (RWE) on post-market assessment of medical devices
Stefania Manetti et al · Cambridge University Press · 2026 · ISSN 1744-1331
The increasing use of real-world evidence (RWE) and real-world data (RWD) to assess post-market medical devices (MDs) might satisfy the urgent need for data sharing and traceability. This study sought to (i) get an overv...
LCC LCC:Public aspects of medicineIdioma eng
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Treatment patterns, treat-to-target goals and clinical outcomes of patients with active lupus nephritis: real-world evidence from a multicentre cohort study
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Treatment patterns, treat-to-target goals and clinical outcomes of patients with active lupus nephritis: real-world evidence from a multicentre cohort study
Joanna Kent et al · BMC · 2026 · ISSN 1478-6362
Abstract Background Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus (SLE). We sought to evaluate treatment patterns, treat-to-target state attainment, and outcomes of patients wi...
LCC LCC:Diseases of the musculoskeletal systemIdioma eng
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Long-term anakinra therapy in Schnitzler syndrome: real-world evidence on remission of neutrophilic dermatitis and systemic inflammation, safety, biomarker insights and dose optimization
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Long-term anakinra therapy in Schnitzler syndrome: real-world evidence on remission of neutrophilic dermatitis and systemic inflammation, safety, biomarker insights and dose optimization
Mariusz Sikora et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
IntroductionSchnitzler syndrome (SchS) is a rare, late-onset, acquired autoinflammatory disorder characterized by recurrent urticarial lesions, monoclonal gammopathy and systemic inflammation. Although interleukin-1 (IL-...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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High serum FSH levels on day 7 of stimulation are negatively associated with oocyte retrieval in GnRH antagonist protocols: real-world evidence from 9,969 IVF cycles in China
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High serum FSH levels on day 7 of stimulation are negatively associated with oocyte retrieval in GnRH antagonist protocols: real-world evidence from 9,969 IVF cycles in China
Xiu Luo et al · Frontiers Media S.A · 2026 · ISSN 1664-2392
This study aimed to investigate how levels of serum follicle-stimulating hormone (FSH) on Day 7 of ovarian stimulation are related to the number of oocytes retrieved, and identify any cutoff or threshold point in protoco...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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Real-World Safety of Trastuzumab Deruxtecan in Patients with HER2-Positive and HER2-Low Metastatic Breast Cancer in Saudi Arabia: A Retrospective Cohort Study
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Real-World Safety of Trastuzumab Deruxtecan in Patients with HER2-Positive and HER2-Low Metastatic Breast Cancer in Saudi Arabia: A Retrospective Cohort Study
Alhuthali AA et al · Dove Medical Press · 2026 · ISSN 1178-7074
Abeer Abdulhadi Alhuthali,1 Abdullah Alshammari,2 Athar Yosuf Jaha,2 Alaa Shahbar,2 Lama Mohammed Almilaibi,3 Reem Saeed Alwadie,2 Alanoud Naher Alghanmi,3 Manal Aljohani,4 Abdullah F Alharthi,5 Mohammed Alnuhait5 1Depar...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience
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Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience
Federica Agosta et al · BMC · 2026 · ISSN 1758-9193
Abstract Background Anti-amyloid monoclonal antibodies are entering clinical practice for early symptomatic Alzheimer’s disease (AD), but European real-world data on feasibility, safety, and biomarker monitoring remain...
LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng
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Real-World Patient Characteristics, Burden, and Quality of Life in C3 Glomerulopathy and Primary Immune Complex Membranoproliferative GN
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Real-World Patient Characteristics, Burden, and Quality of Life in C3 Glomerulopathy and Primary Immune Complex Membranoproliferative GN
Fernando Caravaca-Fontan et al · Wolters Kluwer - Lippincott Williams & Wilkins · 2026 · ISSN 2641-7650
Key Points. C3 glomerulopathy and primary immune complex-mediated membranoproliferative GN lead to a significant clinical, economic, and health care burden among affected patients and their families. C3 glomerulopathy an...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBnZW5pdG91cmluYXJ5IHN5c3RlbS4gVXJvbG9neQ~~Idioma eng
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Impact of a structured nurse-delivered multi component SGLT2 inhibitor initiation and optimization pathway on kidney function and clinical outcomes in type 2 diabetes and chronic kidney disease: a real-world retrospective study
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Impact of a structured nurse-delivered multi component SGLT2 inhibitor initiation and optimization pathway on kidney function and clinical outcomes in type 2 diabetes and chronic kidney disease: a real-world retrospective study
Liang Huang et al · BMC · 2026 · ISSN 1471-2369
Abstract Background The implementation gap between evidence-based SGLT2 inhibitor therapy and real-world practice remains substantial in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Pro...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBnZW5pdG91cmluYXJ5IHN5c3RlbS4gVXJvbG9neQ~~Idioma eng
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Multicenter Real-World Outpatient Use of Intravenous Omadacycline
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Multicenter Real-World Outpatient Use of Intravenous Omadacycline
Lucinda J. Van Anglen et al · Adis, Springer Healthcare · 2026 · ISSN 2193-8229
Abstract Introduction Omadacycline is indicated for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. With limited real-world data, we report the clinical exp...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Demonstrating Clinical Performance of the Elecsys Anti-SARS-CoV-2 Anti-Nucleocapsid Immunoassay Using Real-World Data to Support Regulatory Decision-Making in the USA
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Demonstrating Clinical Performance of the Elecsys Anti-SARS-CoV-2 Anti-Nucleocapsid Immunoassay Using Real-World Data to Support Regulatory Decision-Making in the USA
Eldad A. Hod et al · Adis, Springer Healthcare · 2026 · ISSN 2193-8229
Abstract Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global public health concern. Anti-nucleocapsid (anti-N) serology is a key tool for identifying prior infection and supporting ...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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The OPERA project: a harmonized multinational real-world ART database across Italy and Germany (2016–2020) and a descriptive snapshot of contemporary clinical practice
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The OPERA project: a harmonized multinational real-world ART database across Italy and Germany (2016–2020) and a descriptive snapshot of contemporary clinical practice
Andrea Francavilla et al · Frontiers Media S.A · 2026 · ISSN 2673-3153
IntroductionAssisted reproductive technology (ART) practice varies widely across centers and evolves rapidly, often outpacing the generation of randomized evidence. OPERA (Observational ProjEct for a Research database fo...
LCC TENDOlJlcHJvZHVjdGlvbg~~; TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Efficacy and safety of omadacycline for the treatment of infectious diseases: a real-world, retrospective study of 2587 patients
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Efficacy and safety of omadacycline for the treatment of infectious diseases: a real-world, retrospective study of 2587 patients
Jian Liu et al · Frontiers Media S.A · 2025 · ISSN 1663-9812
ObjectivePrevious randomized controlled trials have shown good efficacy and safety of omadacycline in patients with infectious diseases, but relevant real-world evidence is still insufficient. This large-scale study aime...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Research on interventional treatment strategies for lower extremity deep venous thrombosis based on real-world data
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Research on interventional treatment strategies for lower extremity deep venous thrombosis based on real-world data
Guili Wang et al · Frontiers Media S.A · 2026 · ISSN 2297-055X
ObjectiveCurrent treatment strategies for acute lower extremity deep vein thrombosis (DVT) have shifted from merely preventing pulmonary embolism to actively removing thrombus and preserving valve function. However, ther...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBjaXJjdWxhdG9yeSAoQ2FyZGlvdmFzY3VsYXIpIHN5c3RlbQ~~Idioma eng
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Enhancing Sleep and Mental Health: Longitudinal, Observational, Real-World Study From a Digital Mental Health Platform
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Enhancing Sleep and Mental Health: Longitudinal, Observational, Real-World Study From a Digital Mental Health Platform
Kristen M Van Swearingen et al · JMIR Publications · 2026 · ISSN 2561-326X
Abstract BackgroundPoor sleep is closely linked to mental health challenges and workplace burnout. Mental health and workplace stressors can impair sleep, while good sleep quality supports cognitive and emoti...
LCC LCC:MedicineIdioma eng
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Mental health profile of culturally and linguistically diverse (CALD) women entering New South Wales public prisons: a retrospective cohort study using real-world data
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Mental health profile of culturally and linguistically diverse (CALD) women entering New South Wales public prisons: a retrospective cohort study using real-world data
Reem Zeki et al · BMC · 2026 · ISSN 2050-7283
Abstract Background Women in prison with culturally and linguistically diverse (CALD) backgrounds are at higher risk of marginalisation, isolation, and discrimination than non-CALD women. Despite this, the mental health ...
LCC TENDOlBzeWNob2xvZ3k~Idioma eng
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A deep learning driven framework with ObjTrackNet for real-time object and human detection in smart video surveillance
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A deep learning driven framework with ObjTrackNet for real-time object and human detection in smart video surveillance
L. Abdul Saleem et al · Springer · 2026 · ISSN 2948-2992
Abstract The rising complexity of urban areas, along with growing public safety needs, has made intelligent video surveillance systems more essential. The current surveillance systems that rely on human observation and p...
LCC LCC:Electronic computers. Computer scienceIdioma eng
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Equity and representation in oncology clinical evidence for FDA-approved treatments and the impact of COVID-19
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Equity and representation in oncology clinical evidence for FDA-approved treatments and the impact of COVID-19
Hao Cheng et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundPivotal clinical trials form the evidentiary foundation for FDA oncology drug approvals, yet persistent disparities in participant demographics may limit the generalizability and equity of cancer care. This stu...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Adverse events associated with medical cannabis reported within a centralized call center
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Adverse events associated with medical cannabis reported within a centralized call center
Sílvia M. Illamola et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
IntroductionThe use of medical cannabis products is expanding, yet real-world data on associated adverse events (AEs) remain limited. Controlled trials often exclude diverse patient populations and product types, making ...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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How reliable are ROC cut-offs? Evidence from simulation and empirical analysis
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How reliable are ROC cut-offs? Evidence from simulation and empirical analysis
Yashaswini K et al · BMC · 2026 · ISSN 1471-2288
Abstract Background Receiver Operating Characteristic (ROC) analysis is commonly used to evaluate how well biomarkers distinguish between diseased and non-diseased individuals. A very important step in this process is ch...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Optimizing colorectal cancer screening through polygenic risk score-based risk stratification: evidence from a population-based cohort and screening trial
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Optimizing colorectal cancer screening through polygenic risk score-based risk stratification: evidence from a population-based cohort and screening trial
Hongda Chen et al · BMC · 2026 · ISSN 1756-994X
Abstract Background Accurate risk stratification of colorectal cancer (CRC) is essential for precise screening. Polygenic risk scores (PRS) hold promise for improving predictive efficacy in CRC. However, the real-world a...
LCC LCC:Medicine; LCC:GeneticsIdioma eng
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The pediatric AI readiness framework: bridging evidence to practice in pediatric artificial intelligence
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The pediatric AI readiness framework: bridging evidence to practice in pediatric artificial intelligence
Emre Sezgin et al · Frontiers Media S.A · 2026 · ISSN 2624-8212
Artificial intelligence (AI) presents a transformative opportunity for pediatric healthcare, promising advancements in early diagnosis, personalized treatment, and operational efficiency. However, the unique developmenta...
LCC LCC:Electronic computers. Computer scienceIdioma eng
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A Retrospective Analysis of Radiofrequency Microneedling for Melasma Management in the Japanese Population
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A Retrospective Analysis of Radiofrequency Microneedling for Melasma Management in the Japanese Population
Imaizumi A et al · Dove Medical Press · 2026 · ISSN 1178-7015
Akiko Imaizumi,1 Aira Fujimaki,1,2 Narendra Kumar3 1Department of Dermatology, Imaizumi Skin Clinic, Minato-ku, Tokyo, Japan; 2Department of Hospital Administration, Juntendo University School of Medicine, Tokyo, Japan; ...
LCC LCC:DermatologyIdioma eng
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A decade of InsulinAPP: validation using COSMIN and clinical advancements since its initial publication
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A decade of InsulinAPP: validation using COSMIN and clinical advancements since its initial publication
Toyoshima Marcos Tadashi Kakitani et al · BMC · 2025 · ISSN 1758-5996
Abstract This correspondence marks the 10-year milestone of InsulinAPP, a Brazilian-developed electronic glycemic management system (eGMS) designed to support inpatient insulin therapy. Initially published in 2015, Insul...
LCC LCC:Nutritional diseases. Deficiency diseasesIdioma eng
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