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Open science teaching is becoming more common in higher education but introducing it to younger students can be equally valuable. Teaching open science early can prepare students for scientific careers, and enhance their...

Abstract Bacterial chromosomes are organized by condensins, such as Structural Maintenance of Chromosomes (SMC) proteins. In Streptomyces, a genus of sporulating bacteria, SMC proteins align chromosomal arms and promote ...

Abstract DNA replication timing (RT) often correlates with transcription during cell fate transitions, yet notable exceptions indicate a complex relationship. Using a reductionist system in mouse embryonic stem cells, we...

Abstract Background Rodents are reservoirs of zoonotic viruses that significantly threaten public health. This study investigated the RNA virome of 624 rodents collected across six ecological zones in Yunnan Province, Ch...

Abstract Background The ecdysone receptor (EcR) is a central regulator of mosquito physiology, best known for its role in vitellogenesis. However, its contribution to antiviral defense and dengue virus (DENV) replication...

The main obstacle of influenza is that only a small proportion of cases progress to severe disease due to massive viral replication and excessive immune responses, while effective therapeutics for influenza-induced pneum...

The validity of research findings critically depends on the selection of software samples. However, Mining Software Repositories studies often rely on outdated datasets and lack systematic, transparent procedures for rep...

Brucellosis, a zoonotic disease, triggers severe inflammation and reproductive complications in both humans and animals. The standard treatment protocol relies on prolonged antibiotic courses, often combining streptomyci...

Abstract Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HH...

Purpose – This study aims to determine the effectiveness of NHT Cooperative Learning assisted by Lumi Education in improving the abductive reasoning skills of junior high school students in science lessons on substance...

Abstract The activating signal co-integrator 1 complex subunit 3 (ASCC3), a multifunctional protein, has been implicated as a prognostic marker in several types of cancer. However, mechanisms underlying its prognostic va...

Background Mentalization supports emotion regulation and interpersonal functioning, and meaning in life is a key psychological resource in nursing. This study examined associations between mentalizing capacity and meanin...

Abstract Soil acidity is a critical constraint limiting crop productivity and nutrient availability in upland cropping systems. Acidic soils impede plant growth by reducing nutrient solubility and disrupting key soil pro...

Adenosine deaminase 1-deficient severe combined immune deficiency (ADA-SCID) has widely been attributed to the toxic accumulation of adenine deoxyribonucleotides (dAXP) derived from 2’-deoxyadenosine (dAdo). The presen...

Background. Viral infections remain a major global health threat despite advances in vaccines and antiviral drugs due to the rapid emergence of resistance and new viral pathogens. Antiviral peptides (AVPs) are promising ...

Abstract Many African countries are experiencing hunger and poverty due to the Striga spp. problem. This study was conducted to evaluate the agronomic performance of sixteen (17) resistant genotypes and one (1) susceptib...

Background and ObjectiveDifferentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is clinically difficult, especially when patients are seronegative for anti–aquaporin-4 immunoglobulin...

Abstract Objective Intestinal organoids serve as important tools for drug screening, but the extent to which they recapitulate in vivo tissue microenvironments and drug responses remains inadequately evaluated. This s...

Objective To examine associations between participants’ perinatal factors, including harmonised birth weight and length, prematurity, exposure to maternal smoking during pregnancy and breastfeeding during infancy, and ...

ABSTRACT Adopting conservationist soil use and management practices, such as the no-tillage system and cover crops associated with organic agriculture, can improve the quality of fragile soils. This study aimed to evalua...

S-adenosylhomocysteine (SAH) hydrolase deficiency is a rare autosomal recessive disorder caused by pathogenic variants of the gene AHCY. Loss of SAH hydrolase causes SAH accumulation and impairs the methionine/S-adenosyl...

Abstract Biofortification is a sustainable approach to reduce Zn deficiency in Sub-Saharan Africa, yet the efficiency of common beans (Phaseolus vulgaris L.) in Zn uptake and translocation remain unclear. This study exam...

Abstract Objective Streptococcus shenyangsis is a recently reported member of the genus Streptococcus, rarely detected in the human oral cavity and for which genomic information remains limited. To broaden our understand...

Fowl adenovirus serotype 11 (FAdV-11) causes inclusion body hepatitis, posing a persistent threat to poultry health. However, the genetic determinants governing its pathogenicity remain unclear. Comparative analysis of p...