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Abstract The Murujuga Archipelago, Western Australia, hosts over one million petroglyphs that preserve indigenous knowledge spanning 50,000 years. This globally significant and newly UNESCO-listed world heritage site is ...

The historical background of the rock subculture’s political engagement and cultural relevance in Lithuania, along with photography’s role in shaping and establishing society’s collective identity, suggests that th...

IntroductionThe deserts of Saudi Arabia are rich in rock art and cultural heritage sites, with ancient murals in the AlUla region holding significant symbolic meaning. Heritage plays an important role in preserving cultu...

Abstract The growing importance of machine learning in geological data computing, as well as in the broader geoscience and energy sectors, makes it essential to evaluate the impact of data augmentation on model performan...

Mineral-associated organic matter, the dominant form of relatively stable carbon (C) in soil, often co-occurs with reactive iron (Fe) and aluminum (Al) phases across soils. Yet, how organo-metallic associations at the mo...

One foundational goal of global health and a shared inspiration for all humankind is to reduce premature mortality from preventable and treatable conditions. This imperative becomes markedly more urgent for the uniquely ...

BackgroundHyper IgE syndrome from dominant-negative STAT3 mutations is a multisystem disease with vascular complications. Following a myocardial infarction (MI) from a coronary artery aneurysm in a 43-year-old patient, o...

This study presents PrimDx, a diagnostic test that applies machine learning (ML) to whole blood transcriptomic data to improve early detection and diagnosis of primary immunodeficiency (PID). Delays in PID diagnosis are ...

Artemis-deficient severe combined immunodeficiency (SCID) is a rare autosomal recessive disorder caused by pathogenic variants in DCLRE1C, which encodes ARTEMIS, a DNA repair endonuclease essential for V(D)J recombinatio...

BackgroundAutoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare monogenic autoimmune disorder caused by mutations in the AIRE gene and is characterized by immune dysregulation with multi-organ...

ARM-based systems are widely deployed in edge and IoT settings, where penetration-testing tools must operate under strict memory, power, and thermal constraints, yet prior work offers limited deployment-oriented guidance...

This study explores the potential of cultural tourism as a strategic driver for sustainable urban development in Hail City, Saudi Arabia, emphasizing its alignment with the objectives of Saudi Vision (2030). Situated at ...

Abstract The stability of surrounding rock is a critical challenge in underground engineering. Accurate prediction of Excavation Damaged Zone Thickness (EDZT) in surrounding rock is vital for designing safe underground s...

Serum sickness is an immune complex-mediated hypersensitivity reaction, classically manifested by the triad of fever, rash, and arthralgias. It results from the formation and deposition of antigen–antibody complexes, l...

IntroductionKabuki syndrome (KS) is a rare, complex, multisystem, neurodevelopmental congenital disorder with characteristic phenotypic anomalies and pathogenic genetic variants of the KMT2D or KDM6A genes. KS is highly ...

Immune dysregulation can lead to autoimmunity and autoinflammation. The goal of treatment is to balance targeted therapies while avoiding infections or other side effects, which becomes complicated with multiple diagnose...

Deficiency in ELF4, X-linked (DEX) is a monogenic autoinflammatory disorder caused by loss-of-function (LOF) mutations in the ETS transcription factor ELF4. This rare disorder primarily affects young, male patients due t...

IntroductionIndividuals with inborn errors of immunity (IEI) are increasingly reaching reproductive age, yet guidance on fertility preservation, genetic counseling, medication adjustments in pregnancy and breastfeeding, ...

To address the difficulty of blasthole detection during the charging phase of drill-and-blast tunnelling, which is aggravated by dust interference and insufficient illumination, this study proposes an intelligent blastho...

IntroductionPathogenic variants in the COPA gene are associated with autosomal-dominant autoimmune interstitial lung, joint, and kidney disease, a condition known as COPA syndrome. It is associated with a type I interfer...

ObjectiveApproximately half of common variable immunodeficiency (CVID) patients develop debilitating and life-threatening clinical manifestations of immune dysregulation, including lymphoproliferation, cytopenias, inters...

Although Brazil has experienced substantial immigration from the Middle East and Italy, regions with a higher prevalence of pyrin-associated autoinflammatory diseases, pyrinopathies, remain under-investigated in the coun...

BackgroundPyoderma gangrenosum (PG) is a rare ulcerative neutrophilic dermatosis that can be associated with primary immunodeficiencies. Its pathogenesis is incompletely understood, but it has been increasingly reported ...

RELA-related disease is a rare, autosomal-dominant condition presenting with immune dysregulation and immunodeficiency. RELA encodes the p65 subunit, a component of the canonical NFκB pathway. The underlying pathogenesi...