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Abstract The purpose of this study was to evaluate how universal adhesives affected the proliferation of gingival fibroblasts and human dental pulp stem cells by measuring cell viability at different time points: 1 min,...

Abstract Aim Periodontitis can impair the osteogenic function of periodontal ligament stem cells (PDLSCs), thereby compromising their capacity for periodontal tissue regeneration. In this study, we explored the impact of...

Abstract Background To compare the antibacterial activity of conventional intracanal medicaments used in regenerative endodontic treatment (TAP, DAP, Ca(OH)₂, CHX gel) with novel hydrogel-based formulations (chitosan, ...

This study aims to examine the role of exosomes derived from human urine-derived stem cells (hUSCs-Exo) in the in vitro construction of a composite structure comprising hUSCs and a porcine urethral decellularized matrix...

Abstract Background Mesenchymal stem cells (MSCs) have become a promising treatment of liver fibrosis which is a key process in liver diseases. Recent studies have shown that transplanted MSCs undergo rapid apoptosis and...

Abstract Background Matrix stiffness is a key feature of the mechanical microenvironment. Periodontal tissue is a multicomponent structure composed of cementum, periodontal ligament, and alveolar bone, and is essential f...

Introduction and aims: Human dental pulp stem cells (hDPSCs) play pivotal roles in the regeneration of pulp-dentin complex, yet their odontogenic differentiation is critically modulated by the inflammatory microenvironme...

Objective: Phosphatase and tensin homolog (PTEN) is a critical regulator of cell proliferation, differentiation, and inflammatory balance. However, its downstream proteomic effects in periodontal ligament stem cells (PDL...

Anterior-posterior (AP) spatial regionalization is crucial for central nervous system development. Previous studies suggest that morphogen gradients can induce AP patterning in animal and organoid models. While self-orga...

Abstract Background Adipose tissue is increasingly recognized as an important component of the tumor microenvironment of colorectal cancer (CRC) and actively contributes to the progression of the disease. Adipose stem ce...

Abstract Background Pulmonary injury in sepsis often develops into acute respiratory distress syndrome (ARDS), in which the polarization state of alveolar macrophages (AMs) is a central pathogenic factor. Bone marrow mes...

Abstract Neuroinflammation is a key pathogenic factor for neurodegenerative diseases. Mesenchymal stem cell (MSC) transplantation, as a potential strategy for regulating neuroinflammation, has received extensive attentio...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

ABSTRACT Retinal ganglion cell (RGC) degeneration represents a cardinal etiology of irreversible vision loss in glaucoma, where efficacious regenerative therapies remain scarce. RGC replacement therapy holds promise for ...

Abstract Background Metformin has emerged as a potential bioactive agent in regenerative medicine; however, its optimal concentration for enhancing dental pulp stem cell (DPSC) function remains unclear. This study evalua...

A pathological shift in bone marrow mesenchymal stem cell (BMSC) differentiation towards adipogenesis at the expense of osteogenesis is a key cellular driver of osteoporosis induced by glucocorticoids or estrogen deficie...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

Mesenchymal stem cells (MSC) transplantation had been shown to have a potential for reducing chronic pain. MSC transplantation suppresses excessive inflammation, and one of the potential mechanisms of action is a gap jun...

IntroductionThe secretome derived from Mesenchymal Stem Cells (MSCs) have received significant attention as a promising tool in regenerative medicine. This “cell-free” strategy offers a promising alternative to stem ...

Abstract Intracerebral hemorrhage (ICH) is a devastating neurological condition with high mortality and morbidity. Despite advancements in medical and surgical treatments, the long-term prognosis of ICH remains poor. Ste...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

Thymic stromal cells drive T cell development by supplying key cues for progenitor proliferation and differentiation. Although thymic epithelial cells are well characterized, recent studies highlight crucial functions of...

Abstract Background Signaling molecules play a critical role in regulating stem cell-mediated bone regeneration. In this study, we investigated the effect of EphB4 gene transfection on the osteogenic differentiation and ...

Stem cell therapy, a highly recognized approach in the field of regenerative medicine, is known for its potential to stimulate the self-healing process of the body using stem cells or their derivatives, in which urine-de...