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Abstract Physiological interpretations of Systems Biology have made many advances since the Principles of Systems Biology were first published in this journal in 2008. Those advances show that the main principle, Biologi...

Materias / palabras clave: systems biology, systems physiology, genomics, immunology, proteomics, intermolecular interactions; Science: Physiology

Materias / palabras clave: complex biological networks, molecular biology, systems biology, cellular dynamics, biological modelling; Science: Biology (General)

Materias / palabras clave: systems biology, computational biology, synthetic biology, systems medicine; Science: Biology (General); Medicine: Medicine (General)

Materias / palabras clave: systems biology, bioinformatics, computational systems biology, molecular biology; Science: Biology (General)

Rapid progress of experimental biology has provided a huge flow of quantitative data, which can be analyzed and understood only through the application of advanced techniques recently developed in theoretical sciences. O...

B cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmu...

Ants are essential components of ecosystems, playing critical roles in nutrient cycling, pest control, and soil health. Agricultural practices significantly influence ant biodiversity, yet studies on this subject remain ...

Se muestrearon las plantas vasculares presentes en tres tipos de afloramientos rocosos del municipio de Suesca, departamento de Cundinamarca (Colombia), ubicados entre 2.800 y 3.000 m de altitud. Estos afloramientos se d...

This study investigates a fractional partial differential equation in the field of mathematical biology. The Bernoulli (G'⁄G)-expansion method is applied to solve this class of fractional-order nonlinear differential e...

Microbial siderophores are low-molecular-weight compounds with a strong affinity for ferric (FSe3+) ions. They play a pivotal role in plant-microbial interactions by enhancing iron bioavailability to plants, primarily th...

Mathematics and computer science play a pivotal role in modern biology. Dynamical models based on differential equations are particularly adapted to describe dynamic behaviors of many biological processes. However, tradi...

Abstract The past 25 years have seen remarkable progress in plant circadian biology. This perspective highlights major advances in our understanding of the oscillator network, the processes it regulates, and circadian va...

Although vaccination remains one of the most impactful interventions in contemporary public health, with consistent and widely documented reductions in morbidity and mortality, the traditional empirical development of va...

Abstract Background Protein-protein interaction (PPI) network-based protein function prediction algorithms, which use the guilt-by-association principle, are widely applied in medical and human domains, but they are comp...

Developmental plasticity, the ability to regulate aspects of development in response to environmental cues, is hypothesized to evolve in response to environmental heterogeneity and may facilitate dispersal, novel habitat...

ABSTRACT Genome engineering plays a crucial role in the rapidly growing fields of metabolic engineering and synthetic biology. Chromosomal integration and stable expression of functional genes or large metabolic pathways...

Abstract Many sulfated polysaccharides (SPSs) possess useful physicochemical properties and biological activities and are widely used in industry. Currently, major SPSs are derived from livestock and marine organisms. To...

Abstract Objectives This dataset was specifically collected to support the development and evaluation of computer-aided diagnosis (CAD) systems for breast cancer detection. The dataset, Ma’amon Diagnostic Center Mammog...

Abstract Background Tuberculosis remains a major public health challenge in Somalia, where a fragile health system and reliance on private providers complicate care. Although Public-Private Partnerships are globally reco...

In recent years， quantitative microbial risk assessment （QMRA） for food safety has developed rapidly both domestically and internationally. QMRA integrates multidisciplinary theoretical knowledge and technical meth...

Differential scanning fluorimetry (DSF) using the inherent fluorescence of proteins (nDSF) is a popular technique to evaluate thermal protein stability in different conditions (e.g. buffer, pH). In many cases, ligand bin...

Craniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation...