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BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

Abstract Immunotherapy serves as the fourth modality for cancer treatment, following surgery, radiotherapy, and chemotherapy. However, its efficacy remains inconsistent due to the heterogeneity of the tumor microenvironm...

Abstract Dormant cancer cells are a significant source of cancer recurrence and metastasis and exhibit robust resistance to conventional therapies. Therefore, the exploration of novel therapeutic strategies to eliminate ...

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovial inflammation, progressive cartilage destruction, and bone erosion. Although there have been significant improvements in the use of conventio...

Background: Targeted radioligand therapy (TRT) is an emerging theranostic modality in oncology. While well established in neuroendocrine and prostate cancers, its role in small cell lung cancer (SCLC) and non-small cell ...

Materias / palabras clave: cancer metabolism; cancer therapeutics; drug discovery; precision medicine; targeted therapy

Cancer is a global health public issue with an increasing morbidity and mortality. Ferroptosis is a form of regulated cell death characterized by iron accumulation and lipid peroxidation, providing a novel and promising ...

Aleksander Kielbik,1– 3 Veronika Bahlinger,3,4 Christian M Schürch,3,4 Maria Luisa Barcena,2 Olesya Vakhrusheva,2 Anita Thomas,5 Igor Tsaur,2 Jonas S Heitmann,1,3 Helmut R Salih,1,3,6 Ilona Hagelstein1,3,6 1Clinical C...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Yue Hu,1,2 Peichen Xie,2 Jialin Li,2 Rui Liu,2 Haotong Wang,2 Zhicheng Wang,2 Chunyan Liu1 1Department of Radiology, The Second Hospital of Jilin University, Changchun, People’s Republic of China; 2NHC Key Laboratory o...

Abstract Theileriosis, a tick-borne disease caused by apicomplexan parasites of the genus Theileria, poses a major constraint to livestock productivity worldwide. Existing chemotherapeutics are increasingly limited by ho...

Abstract Among the epidermal growth factor receptor tyrosine kinases (EGFR) family, HER3 (Human epidermal growth factor receptor3) stands apart due to its minimal inherent intracellular kinase function. Its kinase domain...

This commentary discusses the FDA’s drug approvals in 2025, with a particular focus on cancer therapies and the role of companion diagnostics (CDx). Cancer has emerged as the leading therapeutic area, accounting for 35...

Diffuse large B cell lymphoma (DLBCL) presents a critical clinical challenge due to declining chemosensitivity and difficult-to-manage dose-limiting toxicities. Although gut microbiota modulation shows potential for “t...

Abstract Background Hepatocellular carcinoma (HCC) is a critical condition characterized by unchecked cellular growth in the liver, often leading to systemic inflammation and organ failure. Although its complex molecular...

S-palmitoylation, a key reversible lipid post-translational modification, entails the covalent conjugation of palmitic acid chains to the thiol groups of cysteine residues in proteins. This modification modulates protein...

Despite the success of HER2-targeted antibody-drug conjugates (ADCs) in common cancers, there is a lack of real-world evidence regarding their role in rare tumors where ERBB2 gene amplification by next-generation sequenc...

Abstract Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disease characterized by behavioral abnormalities, memory loss, and cognitive decline, presenting significant challenges for early diag...

Background: Guidelines do not recommend routine glycoprotein IIb/IIIa inhibitors (GPIs), reserving them for high thrombotic-risk or bailout cases. Most acute coronary syndrome (ACS) patients undergoing percutaneous coron...

We report a case of a 51-y-old female presenting with synchronous double primary malignancies: advanced endometrial cancer and early-stage lung cancer. One year a post-chemotherapy withdrawal due to toxicity, she develop...

IntroductionAxillary bromhidrosis is characterized by excessive sweat gland activity and foul body odor, significantly affecting patients’ psychological well-being and social interactions.MethodsThis study recruited 30...

Abstract Background Sarcomas comprise a heterogeneous group of aggressive mesenchymal malignancies with limited therapeutic options and poor prognosis, underscoring the need for novel treatment strategies. Fibroblast act...

Lutetium-177 (177Lu)-prostate specific membrane antigen (PSMA)-617 is a small-molecule radioligand therapy (RLT) drug targeting PSMA. By selectively delivering the β－ radiation emitted by 177Lu to PSMA-positive prosta...

Abstract Background Patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who failed bispecific antibody (BsAb) therapy face an extremely poor prognosis, necessitating exploration of effective salva...