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Objective: The aim of the study was to analyze the indications, efficacy, and complications of therapeutic plasma exchange (plasmapheresis) applied for renal diseases in three years retrospectively. Materials and Metho...

The route of administration is a crucial determinant of the success of stem cell-based therapies, especially in intraocular applications. It significantly influences therapeutic outcomes and the risk of adverse events. W...

Abstract Background Senegal lilac (Lonchocarpus sericeus (Poir.)) is a medicinal plant with a long history of folkloric use in the treatment of pathological conditions, particularly gastric ulceration. Aim This study was...

Market definition is fundamental to EU competition law. It serves as a preliminary step in assessing dominance, anti-competitive conduct, and merger control. With respect to the pharmaceutical sector, traditional approac...

Abstract Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles i...

Abstract Ulcerative colitis remains a challenging clinical condition due to its complex etiology and the limitations of current therapies. Plant-derived exosome-like nanovesicles (PDELNs) represent a new class of natural...

Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the e...

Cutaneous lymphatic vessels are essential for maintaining tissue homeostasis and coordinating immune defence, making them vital to skin health. Recent advances in molecular biology and immunology have revealed the associ...

Abstract The early and accurate diagnosis of acute myocardial infarction (AMI) remains a significant clinical challenge. To this end, we profiled the surface proteome of individual plasma extracellular vesicles (EVs) fro...

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...

Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...

Abstract Objective To explore and describe sociodemographic characteristics, crack consumption patterns, and psychiatric comorbidities of female crack users receiving treatment at therapeutic communities. Methods Thi...

ObjectivesAlthough therapeutic drug monitoring (TDM) for isavuconazole (ISA) is not routinely recommended, its utility in specific populations remains debated. This study aimed to elucidate the need for ISA TDM and to id...

Aortic diseases (aortic aneurysm, aortic dissection, atherosclerosis) represent a substantial clinical and economic burden due to the lack of effective early diagnostic tools and mechanism-based therapies. Metabolomics, ...

Protein arginine methyltransferase 3 (PRMT3) is a type I arginine methyltransferase that catalyzes asymmetric dimethylation of arginine residues on diverse substrate proteins. Initially characterized as a regulator of ri...

ABSTRACT Background HIV is a significant aetiological factor in thrombotic microangiopathy (TMA) in regions of high seroprevalence, but description of HIV‐associated TMA (HIV‐TMA) remains limited to small case series...

Examinaram-se possíveis relações entre mudanças no padrão de relacionamento conflituoso de paciente, de 48 anos, submetida a psicoterapia breve psicodinâmica, e a estratégia terapêutica adotada pela terapeuta. Fo...

Non-infectious uveitis encompasses a diverse array of autoimmune ocular disorders marked by the breakdown of immune tolerance and recurrent inflammatory episodes. Regulatory T cells (Tregs) are integral to the maintenanc...

Abstract Background Therapeutic Communities (TCs) are long-term residential treatment settings for individuals with substance use disorders, who often present with neuropsychological impairments. These impairments may in...

ABSTRACT The study involved isolation and identification of (50) isolates Lactobacillus gasseri from the feces of breastfed neonates aged (1-4 months) in Mosul. The ability of the bacteria to reduce the concentration of ...

ABSTRACT Background and Aim Post‐acute sequelae of SARS‐CoV‐2 infection (PASC), commonly referred to as long COVID, has emerged as a significant global health concern, marked by persistent symptoms and chronic infl...

Abstract Background This systematic and meta-analysis review aimed to evaluate the effectiveness of therapeutic exercises on the lower limbs in individuals with joint hypermobility syndrome. Main body of the abstract Thi...

Objective: Both good therapeutic bond as well as extra-therapeutic social support seem to enhance treatment outcomes. Some features of the therapeutic bond are similar to experiences in extra-therapeutic relationships (e...

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast carcinoma which lacks estrogen receptors, progesterone receptors and HER2 along with limited therapeutic options mainly based on chemothera...