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IntroductionThe limited availability of suitable scaffolds for three-dimensional (3D) cell culture has driven the development of new biomaterials. In this study, we developed a porcine fibrin matrix gel (PFMG) derived en...

ABSTRACT Spinal cord injury (SCI), which is a severe complication of spinal fractures, often causes the dysfunction of the spinal cord and results in sensory and motor abnormalities. Current clinical treatments—includi...

Materias / palabras clave: Medicine: Internal medicine

Biofabricated scaffolds facilitate bona fide cellular interactions, cell type specification, and the formation of three-dimensional tissue architecture from human pluripotent stem cells (hPSCs). However, xenogenic biomat...

The characteristic oral environment – with its dynamic clearance, moisture, microbial load, and inflammatory potential – makes oral diseases highly prevalent and therapeutically challenging. Metal-organic frameworks ...

Abstract Using biomedical foundation models (FMs) for inference on small cohorts, represents a promising and practical route to advance drug response biomarker discovery and target identification. Here, we demonstrate th...

The rising concern of antimicrobial resistance, coupled with the continually challenging management of complicated diseases such as cancer, has provided momentum toward precision molecular medicine. This review provides ...

Abstract Inflammatory diseases remain a major clinical challenge due to their complex pathologies and the limitations of current anti-inflammatory therapies. Conventional treatments, such as non-steroidal anti-inflammato...

The invasive brain-computer interface (BCI) is a method that involves implanting microelectrodes into brain tissue to collect neural electrical signals. The signals obtained through this method are often of high precisio...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

La integración entre biotecnología y nanotecnología conforma la bionanotecnología que es una disciplina que permite potenciar la utilización de biomoléculas con materiales abióticos de diseño a escala nanométric...

Abstract Background The ability to guide stem cells toward the bone-forming lineage is a fundamental aspect of regenerative medicine. Conventional protocols for osteogenic differentiation of mesenchymal stem cells typica...

Abstract One of the biggest challenges in tissue engineering and regenerative medicine is to ensure oxygen supply of cells in the (temporary) absence of vasculature. With the vision to exploit photosynthetic oxygen produ...

New emerging approaches in tissue engineering include incorporation of metal ions involved in various metabolic processes, such as Cu, Zn, Si into bioceramic scaffolds for enhanced cell growth and differentiation of spec...

Xenotransplantation is viewed as the most promising way to overcome the problems of shortage of donor organ. It can be exploited from rapidly expanding capabilities in genetic engineering for xenotransplantation. The maj...

Colorectal cancer (CRC) ranks third in incidence among all malignancies and is highly lethal in advanced stages. Combination chemotherapy regimens based on 5-fluorouracil (5-FU) remain the mainstay of colorectal cancer t...

Abstract Background Current bone tissue engineering scaffolds face challenges such as inadequate mechanical support, limited biocompatibility, and suboptimal osteogenesis for treating critical-sized bone defects. This st...

The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in human health care. A new field, tissue engineering, applies the principles of biology and engineering to the deve...

Materias / palabras clave: Reticular connective tissue; Nanotechnology; Porosity; Solid-state; Materials science; Process (computing); Computer science; Engineering physics; Engineering; Composite material; Operating system; Medicine

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical ...

BACKGROUND AND PURPOSE: The etiology of ischemic stroke affects prognosis, outcome, and management. Trials of therapies for patients with acute stroke should include measurements of responses as influenced by subtype of ...

Materias / palabras clave: biomaterials, biomedical engineering, materials science, tissue engineering, regenerative medicine, nanotechnology; Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and const...