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Materias / palabras clave: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology

Materias / palabras clave: anatomy, translational research, application of basic research at clinical level, human pathology; Science: Human anatomy

Materias / palabras clave: Electronic data capture; Workflow; Metadata; Computer science; Translational research informatics; Software deployment; Software; Translational research; Interoperability; Process (computing); Data science; Software engi...

Basic research involving animal models is an important tool to improve our understanding of clinical conditions related with anxiety and panic attacks. In fact, animal models have been used to study several paradigms on ...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with strong invasiveness, limited treatment options, and poor prognosis. Its early accurate diagnosis and individualized treatment are major challenges f...

Team science is central to clinical and translational research; however, systematic evaluation of collaborative efforts remains inconsistent and underdeveloped. To better understand current team science evaluation practi...

Abstract Background Disruption of cellular proteostasis leads to the accumulation and persistence of pathogenic proteins that drive oncogenesis. Key oncogenic and tumor suppressor proteins are frequently dysregulated in ...

Abstract Background Metabolism-induced post-translational modifications (PTMs) are critical for the regulation of cellular activities. As important types of modifications, lactylation and acetylation play essential roles...

ABSTRACT Background and Aims Patient and public involvement and engagement (PPIE) in research is crucial for producing knowledge that is meaningful to the participating community. Sharing PPIE principles into practical t...

Successful completion of industry-sponsored clinical trials requires effective collaboration between sponsors and clinical research sites recruiting patients. As pharmaceutical companies specialize in more therapy areas,...

Abstract Heart failure (HF) is a common disease resulting in high morbidity, mortality, and healthcare costs. An important cause of HF is mitral valve regurgitation (MR), which induces left ventricular remodeling and vol...

Abstract Background Cancer immunotherapy has revolutionized the clinical management of cancer due to its promising survival benefits. Although FDA-approved cancer immunotherapy primarily leverages adaptive immunity for t...

Abstract Objective New Zealand White (NZW) rabbits are widely used in interventional radiology research due to their suitability for human-sized treatment and imaging equipment, offering high translational potential. Thi...

PurposeImmune dysregulation and neuroinflammation have been increasingly implicated in depression, and nanotechnology-based approaches are being actively explored for targeted delivery and immunomodulation. However, a sy...

BackgroundMacrophage polarization plays a critical role in shaping the immunosuppressive tumor microenvironment (TME) of prostate cancer (PCa). Tumor-associated macrophages (TAMs), particularly those exhibiting immunoreg...

Recent advances in Alzheimer’s disease research have reshaped how clinical trials are designed and interpreted, particularly through the use of targeted monoclonal antibodies, biomarker-guided enrollment, and novel dru...

Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance i...

Sensorineural hearing loss (SNHL) is a major cause of disability worldwide, characterized by irreversible damage to cochlear hair cells and spiral ganglion neurons. Current treatments such as hearing aids and cochlear im...

Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems. There are no curative treatments for patients with silicos...

Medicarpin (MED) is an isoflavonoid compound derived from traditional Chinese medicine (TCM). Numerous preliminary experimental studies have shown that MED has significant pharmacological effects in the treatment of canc...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Background and aims Meat-borne Staphylococcus aureus (S. aureus) remains a leading global foodborne pathogen harbouring novel enterotoxin genes (NEGs) encoding superantigenic toxins with conditionally enhanced pathogenic...

Neurodegenerative disorders represent a major and growing global health challenge, characterized by progressive neuronal loss, multifactorial pathophysiology, and limited disease-modifying pharmacological options. Increa...

Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Be...