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Although vaccination remains one of the most impactful interventions in contemporary public health, with consistent and widely documented reductions in morbidity and mortality, the traditional empirical development of va...

Abstract Background and objectives Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) has emerged as a promising target for cancer immunotherapy, given its overexpression in various malignancies and low or a...

Tuberculosis (TB) vaccine design relies on the selection of optimal antigens. However, evidence on candidate antigens is scattered across the literature and rarely linked to critical vaccine parameters, such as immune re...

Abstract Understanding the kinetics of nanoparticle vaccine drainage to the lymph nodes and their residence time in these tissues is critical in vaccine development. Evaluating these parameters using conventional techniq...

Abstract Vaccines represent the most cost-effective and efficacious approach for preventing gastrointestinal infections, and adjuvants play a pivotal role in enhancing and modulating immune responses. In this article, ...

ABSTRACT This study was designed to evaluate the extent of the protection for bovine viral diarrhea virus type 2 (BVDV-2) infection, afforded by vaccination with a combo inactivated vaccine, which contains bovine viral d...

Abstract Objective Klebsiella pneumoniae (Kp) is a clinically prevalent opportunistic pathogen, with escalating antimicrobial resistance posing substantial challenges. Current vaccine strategies are constrained by the...

IntroductionThe emergence of immune-evasive SARS-CoV-2 variants has exposed limitations in the breadth and durability of protection conferred by current Spike-based vaccines, highlighting the need for next-generation app...

Abstract Background Infectious bovine keratoconjunctivitis (IBK) in beef cattle has major welfare and production implications. Effective vaccination against IBK would also reduce antibiotic use in beef production. Object...

Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...

This study investigates the health impacts of transitioning from Gavi, the Vaccine Alliance, on vaccination coverage, infant and under-5 mortality, and disability-adjusted life years (DALYs) in low and middle-income coun...

To address the objective in a clinical trial to estimate the mean or mean difference of an expensive endpoint Y, one approach employs a two-phase sampling design, wherein inexpensive auxiliary variables W predictive of Y...

Abstract Despite the demonstrated effectiveness of vaccines, varying levels of hesitancy were observed among healthcare and long‐term care workers, who were prioritized in the roll out of COVID‐19 vaccines due to the...

Objectives: To describe the post-marketing safety profile of respiratory syncytial virus prefusion F (RSVpreF) vaccine among pregnant individuals.Design: This study analysed adverse event (AE) reports submitted to the U....

Abstract Coronavirus disease 2019 (COVID-19) is a pandemic disease that causes serious pulmonary complications. Vaccination is the most effective measure to prevent severe illness and reduce mortality. The Johnson & John...

mRNA vaccines emerged as a leading vaccine technology during the COVID-19 pandemic. However, their sustained protective efficacies were limited by relatively short-lived antibody responses and the emergence of SARS-CoV-2...

The animal disease is caused by the monkey virus, an orthopox virus associated with smallpox. Although endemic to central and western Africa, recent outbreaks in germ-free areas have raised global health concerns. The di...

Abstract Objectives Childhood immunization remains one of the most effective public health interventions, yet coverage gaps persist in northern Nigeria. This study assessed parental knowledge, attitudes, and sociocultura...

Abstract Introduction Varicella, caused by the varicella zoster virus, poses a significant public health challenge, particularly among children. To address this, the city of Shenzhen, China, introduced a publicly funded ...

Abstract Background In Ukraine, historical challenges of vaccination behavior and uptake, rooted in complex social and structural factors, have long hindered efforts to reach the 95% childhood vaccination coverage for he...

Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study was to assess how vaccine delivery routes (homologo...

Kaissar Tabynov,1,2,* Kairat Tabynov,2,3 Nikolai Petrovsky4,* 1International Center for Vaccinology, Kazakh National Agrarian Research University, Almaty, Kazakhstan; 2Preclinical Research Laboratory with...

Computational modeling of protein-protein interactions (PPIs) is a high priority because it is essential for understanding nearly all cellular functions and for addressing the limitations of time-consuming experimental m...